Construction of the anti-aging therapy for the salivary gland functional decline by the aging
| Project/Area Number |
24792223
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アクアポリン５ / 唾液腺 / デシタビン |
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| Outline of Final Research Achievements |
We demonstrate that the in vivo administration of decitabine to the murine aging model mice. Western blot analysis demonstrated the augmented expression of AQP5 protein in the salivary glands of decitabine-treated mice compared to those of control mice. In addition, AQP5 protein expression levels in 5-Aza-CdR-treated old mice (27 weeks old) were much higher than those in untreated and young mice (6 weeks old). Global methylation levels in the salivary glands were significantly lower in the decitabine-treated mice than in the untreated mice. Moreover, the induction of demethylation in the AQP5 promoter of decitabine-treated mice was stronger than in the control mice. Our data therefore suggest that a DNA demethylating agent may be a useful drug for restoring hyposalivation in elderly individuals.
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Report
(4 results)
Research Products
(26 results)
