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Analysis of the mechanism of the condition of a patient formation, the progress of Sjogren's syndrome

Research Project

Project/Area Number 24792230
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

TANAKA Akihiko  九州大学, 大学病院, その他 (70615799)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsThサブセット / サイトカイン / ケモカイン / シェーグレン症候群 / IgG4関連疾患 / リンパ濾胞 / Th細胞
Research Abstract

It was intended to analyze it about the condition of the patient in the lesion local site of Sjogren's syndrome in this study. I examined the local existence of the Th subset in the lesion local site between the same patients between the permeation degree of the lymphocyte of the comparison with the physically unimpaired person and the SS.
It was strong to carry the role that was important to the onset not condition of the patient progress, and both Th1 and Th17 where it permeated around the ductal epithelium of the SS were suggested by this study. Furthermore, in addition to Th1 and Th17, the condition of the patient progressed in what Th2 and Tfh accumulated and it was particularly strong that Th2 and Tfh played an important role for the formation of the GC and was suggested.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (17 results)

  • [Journal Article] Clinical characteristics of Mikulicz's disease as an IgG4-related disease.2013

    • Author(s)
      4. Moriyama M, Tanaka A, Maehara T, Ohyama Y, Shimizu M, Nakashima H, Hayashida JN, Shinozaki S, Kubo Y, Furukawa S, Kikuta T, Nakamura S.
    • Journal Title

      Clin Oral Investig.

      Volume: 17(9) Issue: 9 Pages: 1995-2002

    • DOI

      10.1007/s00784-012-0905-z

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] T helper subsets in Sjögren syndrome and IgG4-related dacryoadenitis and sialoadenitis : A critical review2013

    • Author(s)
      Moriyama M, Tanaka A, Maehara T, Furukawa S, Nakashima H, and Nakamura S
    • Journal Title

      J Autoimmun

      Volume: 3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] T helper subsets in Sjogren’s syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review.2013

    • Author(s)
      Moriyama M, et al.
    • Journal Title

      J Autoimmun.

      Volume: in press Pages: 81-88

    • DOI

      10.1016/j.jaut.2013.07.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selective localization of Th subsets in labial salivary glands from primary Sjögren's syndrome patients2012

    • Author(s)
      Maehara T, Moriyama M, Hayashida J-N, Tanaka A, Shinozaki S, Matsumura K, Kubo Y, and Nakamura S
    • Journal Title

      Clin Exp Immunol

      Volume: 169(2) Pages: 89-99

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine/chemokine profiles contribute to understanding the pathogenesis and diagnosis of primary Sjögren's syndrome2012

    • Author(s)
      Moriyama M, Hayashida J-N, Toyoshima T, Ohyama Y, Shinozaki S, Tanaka A, Maehara T, Nakamura S
    • Journal Title

      Clin Exp Immunol

      Volume: 169(1) Pages: 17-26

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in Mikulicz's disease2012

    • Author(s)
      Maehara T, Moriyama M, Hayashida J-N, Tanaka A, Shinozaki S, Matsumura K, Kubo Y, and Nakamura S
    • Journal Title

      Ann Rheum Dis

      Volume: 71(12) Pages: 2011-20

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients.2012

    • Author(s)
      Maehara T
    • Journal Title

      Clin Exp Immunol.

      Volume: 69 Issue: 2 Pages: 89-99

    • DOI

      10.1111/j.1365-2249.2012.04606.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Polarized M2 macrophages promote fibrosis of glandular tissue in IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS)2013

    • Author(s)
      Furukawa F, Moriyama M, Hayashida J-N, Tanaka A, Maehara T, 他
    • Organizer
      12th International Symposium on Sjögren's Syndrome
    • Place of Presentation
      京都
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] IgG4 関連涙腺・唾液腺炎(IgG4-DS)の病態形成における M2 マクロファージの関与2013

    • Author(s)
      古川 祥子, 森山 雅文, 田中 昭彦, 他
    • Organizer
      第22回日本シェーグレン症候群学会
    • Place of Presentation
      大阪府
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 唾液を用いたドライマウスの新しい診断方法および病態把握の試み2013

    • Author(s)
      大山 恵子、森山 雅文、林田 淳之將、篠崎 昌一、田中 昭彦、前原 隆  家田 晋輔、古川 祥子、中村 誠司
    • Organizer
      第10回 日本口腔ケア学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミクリッツ病/IgG4 関連疾患の臨床的検討2012

    • Author(s)
      森山雅文, 林田淳之將, 田中昭彦, 他
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      神奈川県
    • Related Report
      2013 Final Research Report
  • [Presentation] ミクリッツ病/IgG4 関連疾患の IgG4 産生におけるサイトカイン・ケモカインの関与2012

    • Author(s)
      田中昭彦, 森山雅文, 他
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      神奈川県
    • Related Report
      2013 Final Research Report
  • [Presentation] ミクリッツ病/IgG4 関連疾患の胚中心過形成における IL-21 の関与2012

    • Author(s)
      前原 隆, 森山雅文, 林田淳之將, 田中昭彦, 他
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      神奈川県
    • Related Report
      2013 Final Research Report
  • [Presentation] ミクリッツ病/IgG4 関連疾患の胚中心過形成における IL-21 の関与2012

    • Author(s)
      前原 隆, 森山雅文, 林田淳之將, 田中昭彦, 他
    • Organizer
      第21回日本シェーグレン症候群学会
    • Place of Presentation
      京都府
    • Related Report
      2013 Final Research Report
  • [Presentation] Interleukin-21 Contributes To Germinal Center Formation And Igg4 Production In Mikulicz's Disease2012

    • Author(s)
      Maehara T, Moriyama M, Hayashida J-N, Tanaka A, 他
    • Organizer
      10th Asian Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      インドネシア
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-33 cotributes to the pathogenesis of Sjögren syndrome2012

    • Author(s)
      Furukawa F, Moriyama M, Hayashida J-N, Tanaka A, Maehara T, 他
    • Organizer
      第60回JADR総会・学術大会
    • Place of Presentation
      新潟県
    • Related Report
      2013 Final Research Report
  • [Presentation] ミクリッツ病/IgG4関連疾患の臨床的検討2012

    • Author(s)
      森山雅文, 林田淳之將, 田中昭彦, 前原 隆, 篠崎昌一, 久保慶朗, 古川祥子, 中村誠司
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ミクリッツ病/IgG4関連疾患のIgG4産生におけるサイトカイン・ケモカインの関与2012

    • Author(s)
      田中昭彦, 森山雅文, 林田淳之將, 前原 隆, 篠崎昌一, 久保慶朗, 古川祥子, 中村誠司
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ミクリッツ病/IgG4関連疾患の胚中心過形成におけるIL-21の関与2012

    • Author(s)
      前原 隆, 森山雅文, 林田淳之將, 田中昭彦, 篠崎昌一, 久保慶朗, 古川祥子, 中村誠司
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ドライマウス患者における唾液分泌促進剤の有効性と副作用の検討2012

    • Author(s)
      森山雅文、篠崎昌一、林田淳之將、田中昭彦、大山恵子、前原隆、久保慶朗、家田晋輔、古川祥子、中村誠司
    • Organizer
      第9回日本口腔ケア学会総会・学術集会
    • Place of Presentation
      名古屋学芸大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 九州大学病院ドライマウス外来におけるドライマウスの診断と治療2012

    • Author(s)
      田中昭彦、林田淳之將、森山雅文、篠崎昌一、前原隆、大山恵子、久保慶朗、家田晋輔、古川祥子、中村誠司
    • Organizer
      第9回日本口腔ケア学会総会・学術集会
    • Place of Presentation
      名古屋学芸大学
    • Related Report
      2012 Research-status Report
  • [Presentation] ミクリッツ病/IgG4関連疾患の胚中心過形成におけるIL-21の関与2012

    • Author(s)
      前原 隆, 森山雅文, 林田淳之將, 田中昭彦, 篠崎昌一, 久保慶朗, 古川祥子, 中村誠司
    • Organizer
      第21回日本シェーグレン症候群学会
    • Place of Presentation
      ウェスティン都ホテル京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Interleukin-21 Contributes To Germinal Center Formation And Igg4 Production In Mikulicz's Disease.2012

    • Author(s)
      Maehara, T., Moriyama, M., Hayashida, J.-N., Tanaka, A., Shinozaki, S., Kubo, Yoshiaki, and Nakamura, S.
    • Organizer
      ACOMS 2012 アジア口腔顎顔面外科学会
    • Place of Presentation
      インドネシア バリ
    • Related Report
      2012 Research-status Report
  • [Presentation] IgG4関連涙腺・唾液腺炎(IgG4-DS)の病態形成におけるM2マクロファージの関与

    • Author(s)
      古川 祥子、森山 雅文、田中 昭彦、前原 隆、坪井 洋人、林田 淳之將、大山恵子、太田美穂、住田孝之、中村 誠司
    • Organizer
      第22回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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