Research of genetic factor for CLP using association analysis of candidate genes
Project/Area Number |
24792232
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
|
Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 口唇口蓋裂 / 関連解析 / 候補遺伝子 / 疾患感受性遺伝子 / 遺伝子 / 相互作用 / 遺伝子間相互作用 |
Outline of Final Research Achievements |
To identify the susceptibility genes of multifactorial disorders, the genome-wide association study is useful. Since the enormous number of sample is needed, I decided to use the locus-wide association study in this research. To select candidate genes, I focused on a change in the genetic manifestation at the time of palate organization of a mouse. Palate tissues around the formation period were taken out and genetic manifestation was analyzed using a DNA micro array. Many genes participated in the palate formation, and moreover the genetic manifested pattern was different in a hard palate and a velum. It was considered to develop the symptoms by different mechanisms in each pattern of cleft.
|
Report
(4 results)
Research Products
(4 results)
-
-
[Presentation] 口蓋裂を伴ったPrader-Willi症候群の一例2014
Author(s)
久保田 恵吾, 新井 伸作, 松村 香織, 光安 岳志, 三上 友理絵, 辻口 友美, 笹栗 正明, 長谷川 幸代, 森 悦秀, 中村 誠司
Organizer
第38回日本口蓋裂学会総会・学術集会
Place of Presentation
札幌コンベンションセンター 北海道
Year and Date
2014-05-29 – 2014-05-30
Related Report
-
-