| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
To identify the susceptibility genes of multifactorial disorders, the genome-wide association study is useful. Since the enormous number of sample is needed, I decided to use the locus-wide association study in this research. To select candidate genes, I focused on a change in the genetic manifestation at the time of palate organization of a mouse. Palate tissues around the formation period were taken out and genetic manifestation was analyzed using a DNA micro array. Many genes participated in the palate formation, and moreover the genetic manifested pattern was different in a hard palate and a velum. It was considered to develop the symptoms by different mechanisms in each pattern of cleft.
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