| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The pilot study revealed that a method based on cell sheet technology in which rat bone marrow-derived stromal cells were cultured and formed into a cell sheet structure could repair critical bone defects. We applied this method to stem cells from human exfoliated deciduous teeth (SHEDs) and found that cell sheets prepared from SHEDs had osteogenic capacity in vitro. Next, we adopted a rat mandibular bone defect model and examined them. Although the therapeutic effect was limited, we confirmed their osteogenic capacity in vivo as well. We gained a clue for developing new approach using cell sheet technology and SHEDs towards achieving maxillofacial regeneration.
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