Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines.

Research Project

Project/Area Number	24792254
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Showa University
Principal Investigator	KURIHARA Yuji 昭和大学, 歯学部, 助教 (90514969)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	ウイルス治療 / 口腔がん / テロメライシン / 腺様嚢胞細胞癌 / テロメラーゼ / 口腔癌
Research Abstract	We describe the mechanistic basis for synergy of virotherapy. Our data clearly indicate that telomerase-specific replication-selective oncolytic adenoviruses can significantly inhibit ACC cell growth in vitro and in vivo. Moreover, these viruses can be used in an ex vivo diagnostic assay to predict the therapeutic potential of virus in ACC patients.27 This novel technology will affect and contribute to the minimum operative procedure for ACC cancer patients.

Report

(3 results)