Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines.
| Project/Area Number |
24792254
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ウイルス治療 / 口腔がん / テロメライシン / 腺様嚢胞細胞癌 / テロメラーゼ / 口腔癌 |
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| Research Abstract |
We describe the mechanistic basis for synergy of virotherapy. Our data clearly indicate that telomerase-specific replication-selective oncolytic adenoviruses can significantly inhibit ACC cell growth in vitro and in vivo. Moreover, these viruses can be used in an ex vivo diagnostic assay to predict the therapeutic potential of virus in ACC patients.27 This novel technology will affect and contribute to the minimum operative procedure for ACC cancer patients.
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Report
(3 results)
Research Products
(4 results)
