Study of the Circadian chronotherapy for oral cancer

• Project/Area Number: 24792256
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokai University
• Principal Investigator: OTSURU Mitsunobu 東海大学, 医学部, 講師 (60384864)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔癌 / クロノテラピー / メラトニン / 時計遺伝子

Outline of Final Research Achievements

Oral cancer cells clock gene (Clock, Bmal, Period2, Cry) were measured by RT-PCR revealed development cycle Cry alone.
6 weeks old BALB/c-nu nude mice transplanted oral squamous cell carcinoma cell lines、There was no obvious expression of the clock gene (Cry) was measured by RT-PCR expression cycle.