Basic research of orofacial neuropathic pain mechanisms for novel therapy
Project/Area Number |
24792259
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Nihon University |
Principal Investigator |
SUZUKI Ikuko 日本大学, 歯学部, 研究員 (60459906)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 神経障害性疼痛 / 機械痛覚過敏 / 熱痛覚過敏 / MAPキナーゼ / 三叉神経脊髄路核尾側亜核 / MAPキナーゼ / 三叉神経損傷 |
Research Abstract |
We evaluated the involvement of the mitogen-activated protein kinase (MAPK) cascade in orofacial neuropathic pain mechanisms. The nocifensive behavior was significantly enhanced in chronic constriction nerve injury of the infraorbital nerve (ION-CCI) rat. ION-CCI rats had an increased number of phosphorylated ERK immunoreactive (pERK-IR) cells. After intrathecal administration of the MEK1 inhibitor PD98059 in ION-CCI rats, the enhanced thermal nocifensive behavior but not the mechanical nocifensive behavior were significantly reduced in ION-CCI rats. The responses of wide dynamic range neurons to noxious mechanical and thermal stimulation in ION-CCI rats were significantly depressed following i.t. administration of PD98059, whereas responses to non-noxious mechanical and thermal stimulation were not altered. The present findings suggest that pERK-IR neurons play a pivotal role in the development of thermal hypersensitivity in the face following trigeminal nerve injury.
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Report
(3 results)
Research Products
(3 results)