Basic research of bone tissue regeneration using human dedifferentiated fat cells for clinical application
| Project/Area Number |
24792263
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脱分化脂肪細胞 / 脂肪組織由来幹細胞 / 頬脂肪体 / 骨再生 / 組織工学 / 天井培養 / 脂肪幹細胞 |
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| Research Abstract |
We isolated human dedifferentiated fat (DFAT) cells and adipose-derived stem cells (ASC) from the buccal fat pad, and evaluated and compared the osteoblastic differentiation ability. Bone-specific alkaline phosphatase, osteocalcin, and calcium as osteoblastic differentiation markers within DFAT cell cultures were significantly higher than those in ASC cultures. The osteoblastic differentiation ability of DFAT cells is higher than that of the ASC from the buccal fat pad. We consider that DFAT cells from the buccal fat pad are useful cell source for bone tissue engineering.
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Report
(3 results)
Research Products
(10 results)
