| Project/Area Number |
24792270
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
AONUMA Tomo 東北大学, 大学病院, 医員 (70624823)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | メカニカルストレス / Runx2 / 細胞増殖 / メカノトランスダクション |
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| Research Abstract |
It has been reported that tooth movement in cleidocranial dysplasia(CCD) is delayed. Runx2, its mutation causes CCD, is an essential factor for osteoblastic differentiation and an important factor for mechanical stress. Our group confirmed delayed tooth movement and reduction of response for mechanical stress in periodontal tissue of Runx2 heterozygous mice (Runx2+/- mice), animal model of CCD. In present study, cell proliferation and osteoblastic differentiation in bone marrow stromal cells (BMSCs) derived from Runx2+/- mice during mechanical stretching were investigated. As a result, we found cell proliferation of BMSCs derived from wild-type and Runx2+/- mice and delayed promotion of osteoblastic differentiation of BMSCs after mechanical stretching compared with wild-type mice. We confirmed delayed osteoblastic differentiation on tension side of tooth movement in Runx2+/- mice in vitro.
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