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Development of the artificial bone using phosphorylated pullulan in experimental cleft palate model

Research Project

Project/Area Number 24792271
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

SEIRYU Masahiro  東北大学, 歯学研究科(研究院), 助教 (80510023)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords歯学 / 再生医学 / 細胞・組織
Outline of Final Research Achievements

The purpose of this study is as follows, 1) To evaluate the period of bone healing in extracted sockets of first molars in rats using tricalcium phosphate and phosphorylated pullulan. 2) To create a cleft palate model of rat and beagle. 3) To evaluate the period of bone healing in the cleft palate model of rat and beagle using tricalcium phosphate and phosphorylated pullulan.
The result of this study is as follows, 1) The CT value of the group of tricalcium phosphate and phosphorylated pullulan was higher than other groups. 2) The most suitable mixture ratio of the tricalcium phosphate and phosphorylated pullulan was able to determine. 3) The cleft palate model of rat and beagle were succeeded without any trouble.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Decreased alveolar bone turnover is related to the occurrence of root resorption during experimental tooth movement in dogs.2015

    • Author(s)
      Deguchi T., Seiryu M., Daimaruya T., Garetto LP., Takano-Yamamoto T., Roberts WE.
    • Journal Title

      Angle. Orthod.

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone.2015

    • Author(s)
      Takimoto A., Kawatsu M., Yoshimoto Y., Kawamoto T., Seiryu M., Takano-Yamamoto T., Hiraki Y., Shukunami C.
    • Journal Title

      Development.

      Volume: 142(4) Issue: 4 Pages: 787-796

    • DOI

      10.1242/dev.116228

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway2014

    • Author(s)
      K Hoshi, H Kawaki, I Takahashi, N Takeshita, M Seiryu, S A Murshid, T Masuda, T Anada, R Kato, H Kitaura, O Suzuki, T Takano-Yamamoto
    • Journal Title

      J Bone Miner Res

      Volume: 29 Issue: 5 Pages: 1244-1257

    • DOI

      10.1002/jbmr.2115

    • NAID

      130004695790

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of optimal length and insertion torque for miniscrews2013

    • Author(s)
      Makoto Suzuki, Toru Deguchi, Hisako Watanabe, Masahiro Seiryu, Masahiro Iikubo, Takashi Sasano, Koji Fujiyama, Teruko Takano-Yamamoto
    • Journal Title

      Am J Orthods Dentofacial Orthop

      Volume: 144 Issue: 2 Pages: 251-259

    • DOI

      10.1016/j.ajodo.2013.03.021

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decreases of occlusal vertical dimension induce changes in masticatory muscle fibre composition.2012

    • Author(s)
      Seiryu M; Daimaruya T; Iikubo M; Watanabe K; Takano-Yamamoto T.
    • Journal Title

      Orthodontic Wave

      Volume: 71(4) Issue: 4 Pages: 123-128

    • DOI

      10.1016/j.odw.2012.05.003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increase of CGRP-Containing Nerve Fibers in the Rat Periodontal Ligament After Luxation2012

    • Author(s)
      Nagayama T, Seiryu M, Deguchi T, Kano M, Suzuki T, Takano-Yamamoto T, Ichikawa H
    • Journal Title

      Cell Mol Neurobiol

      Volume: 32(3) Issue: 3 Pages: 391-397

    • DOI

      10.1007/s10571-011-9767-1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone2012

    • Author(s)
      Kim S, Seiryu M, Okada S, Kuroishi T, Takano-Yamamoto T, Sugawara S, Endo Y
    • Journal Title

      Eur J Pharmacol

      Volume: 699(1 -3) Issue: 1-3 Pages: 14-22

    • DOI

      10.1016/j.ejphar.2012.11.031

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 左右非対称な抜歯を行い固定源として矯正用アンカースクリューを用いた前歯部叢生および口唇の突出をともなうAngle ClassI,上顎前突症例2013

    • Author(s)
      金原正敬、清流正弘、山本照子
    • Organizer
      第29回東北矯正歯科学会大会
    • Place of Presentation
      弘前
    • Related Report
      2013 Research-status Report
  • [Presentation] 固定源として矯正用アンカースクリューを用いて下顎全歯列遠心移動を行った下顎前突症例2013

    • Author(s)
      解良洋平、清流正弘、山本照子
    • Organizer
      第29回東北矯正歯科学会大会
    • Place of Presentation
      弘前
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯科矯正用アンカースクリューにおける最適な長さおよび埋入時トルクの評価、Evaluation of optimal length and insertion torque for miniscrew as orthodontic anchorage.2013

    • Author(s)
      鈴木 誠、出口 徹、渡邉 壽子、清流 正弘、飯久保 正弘、笹野 髙嗣、藤山 光治、山本 照子
    • Organizer
      第72回日本矯正歯科学会
    • Place of Presentation
      松本
    • Related Report
      2013 Research-status Report
  • [Presentation] 固定源として矯正用インプラントを用いた著しい偏位およびシザーズバイトを伴った上顎前突症例2012

    • Author(s)
      清流正弘, 土江雄治郎, 出口徹, 台丸谷隆慶, 山本照子
    • Organizer
      第28回東北矯正歯科学会大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 歯根膜におけるScleraxisの発現とその制御2012

    • Author(s)
      滝本晶, 宿南知佐, 川津正慶, 清流正弘, 山本照子, 開祐司
    • Organizer
      第30回日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 非窒素含有bisphosphonatesの骨吸収抑制作用とは関連しない鎮痛効果2012

    • Author(s)
      岡田諭, 金始瑛,清流正弘,山口昇史, 高橋哲, 山本照子,菅原俊二,遠藤康男
    • Organizer
      第54回歯科基礎医学会
    • Place of Presentation
      福島
    • Related Report
      2012 Research-status Report
  • [Presentation] 外科的矯正治療を開始する前に機能的な問題の改善を行った骨格性III級下顎前突症例2012

    • Author(s)
      清流正弘 則松佑佳 台丸谷隆慶 山本照子
    • Organizer
      第71回日本矯正歯科学会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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