| Project/Area Number |
24792279
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
ISHIDA Takayoshi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (90549966)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 歯学 / 脳神経 / 認知科学 / 咬合刺激 / 空間認知記憶 / 成長期 / 咀嚼刺激 |
|---|
| Research Abstract |
Previous studies have reported that cognitive function declines in aged humans or senescence-accelerated mice when masticatory loading decreases. The purpose of the present study was to investigate cognitive functional changes under conditions of low masticatory loading during a growth period. The hypothesis that decreased masticatory loading impaired cognitive function during the growing period was tested. Male Wistar rats, 2 weeks old, were assigned to two groups: control, fed whole pellets; experimental group, fed a liquid diet. Cognitive function was assessed using the 8-radial-maze. Results suggested that decreased masticatory loading during the growth period enhanced hippocampal neuronal loss, which led to impaired cognitive function in growing rats.
|
