| Project/Area Number |
24792281
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 歯科矯正学 / 骨細胞 / カルシウム / 細胞内カルシウム / NO / ギャップ結合 |
|---|
| Research Abstract |
Bone cells respond to mechanical stimuli by producing a variety of biological signals, and intracellular calcium (Ca2+) is an important secondary messenger controlling many cellular processes. Its variety of oscillatory signaling is thought to act in the regulation of many different cell functions including bone metabolisms. However, it has not been entirely clear the behavior and connectivity of the [Ca2+]i signaling networks in mechanotransduction between osteoblasts and osteocytes in integrated bone tissues due to complex bone matrices surrounding bone cells. To address this issue, we have developed a novel ex vivo live Ca2+ imaging system, which made it possible to observe the mechanical stress-induced Ca2+ oscillations.
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