Investigation of stem cell dynamics in epithelial rest of Malassez and molecular control mechanism

• Project/Area Number: 24792282
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Okayama University
• Principal Investigator: SUMIYOSHI Kumi 岡山大学, 医歯(薬)学総合研究科, 助教 (80625161)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯根膜 / マラッセ上皮遺残 / 細胞伝達 / 細胞間伝達 / 幹細胞

Research Abstract

The regulatory mechanism of tissue stem cell and its surrounding environment is not clearly revealed. In the present study, the tissue stem cells were shown to be scattered around the root surface. There were Gap junctions between the periodontal ligaments cell to cell, these expression levels were changed in the hypoxia condition. Therefore, we revealed the part of the mechanism in the maintenance and remodeling at the periodontal tissue.

Research Products

• [Journal Article] Regulation of CCN1 via the 3'-untranslated region (2013)
  • Author(s): Nakagawa Y, Minato M, Sumiyoshi K, Maeda A, Hara C, Murase Y, Nishida T, Kubota S, Takigawa M
  • Journal Title: J. Cell Commun Signal Volume: 7(3) Pages: 207-17
  • Peer Reviewed
• [Journal Article] Gap-junction-mediated communication in human periodontal ligament cells (2013)
  • Author(s): Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
  • Journal Title: J Dent Res Volume: 92(7) Pages: 635-40
  • Peer Reviewed
• [Journal Article] Novel role of miR-181a in cartilage metabolism (2013)
  • Author(s): Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Abd El Kader T, Nishida T, Ikeda N, Shimo T, Yamashiro T, Takigawa M
  • Journal Title: J Cell Biochem Volume: 114(9) Pages: 2094-100
  • Peer Reviewed
• [Journal Article] Gap junction-mediated communication in human periodontal ligament cells (2013)
  • Author(s): Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T and Yamashiro T
  • Journal Title: JDR Volume: 92(7) Issue: 7 Pages: 635-40
  • DOI: 10.1177/0022034513489992
  • Peer Reviewed
• [Journal Article] Regulation of CCN1 via the 3’-untranslated region. (2013)
  • Author(s): Nakagawa, Y., Minato, M., Sumiyoshi, K., Maeda, A., Hara, C., Murase, Y., Nishida, T., Kubota, S. and Takigawa, M.:
  • Journal Title: J. Cell Commun. Signal., 7, 207-217, 2013. Volume: 7 Issue: 3 Pages: 207-217
  • DOI: 10.1007/s12079-013-0202-x
  • Peer Reviewed
• [Journal Article] Novel role of miR-181a in cartilage metabolism. (2013)
  • Author(s): Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Abd El Kader T, Nishida T, Ikeda N, Shimo T, Yamashiro T, Takigawa M
  • Journal Title: J Cell Biochem Volume: in press Issue: 9 Pages: 2094-100
  • DOI: 10.1002/jcb.24556
  • Peer Reviewed
• [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間コミュニケーションの骨代謝へ及ぼす影響 (2013)
  • Author(s): 加藤龍史, 石原嘉人, 川邉紀章, 住吉久美, 吉川祐介, 福島宏明, 上岡寛, 山本照子, 山城隆
  • Organizer: 第72回日本矯正歯科学会大会
  • Place of Presentation: 松本市
• [Presentation] Gap junction-mediated communication in human periodontal ligament cells (2013)
  • Author(s): Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
  • Organizer: NIH-Tohoku University-JSPS Symposium
  • Place of Presentation: Sendai. Japan
• [Presentation] Gap junction-mediated communication in human periodontal ligament cells. (2013)
  • Author(s): Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto
  • Organizer: NIH-Tohoku University-JSPS Symposium
  • Place of Presentation: 仙台市
• [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間伝達は低酸素環境下において抑制的に調節される (2012)
  • Author(s): 加藤龍史, 石原嘉人, 川邉紀章, 住吉久美, 吉川祐介, 今井裕一, 上岡寛, 山本照子, 山城隆
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡市
• [Presentation] イノシトール三リン酸は生きた骨組織中における細胞内カルシウム応答の必須因子である (2012)
  • Author(s): 石原嘉人, 菅原康代, 上岡寛, 川邉紀章, 柳田剛志, 住吉久美, 山城隆
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡市
• [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間伝達は低酸素環境下において抑制的に調節される (2012)
  • Author(s): 加藤 龍史, 石原 嘉人, 川邉 紀章, 住吉 久美, 吉川 祐介, 今井 裕一, 上岡 寛, 山本 照子, 山城 隆
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡
• [Presentation] イノシトール三リン酸は生きた骨組織中における細胞内カルシウム応答の必須因子である (2012)
  • Author(s): 石原 嘉人, 菅原 康代, 上岡 寛, 川邉 紀章, 柳田 剛志, 住吉 久美, 山城 隆
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡