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Investigation of stem cell dynamics in epithelial rest of Malassez and molecular control mechanism

Research Project

Project/Area Number 24792282
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOkayama University

Principal Investigator

SUMIYOSHI Kumi  岡山大学, 医歯(薬)学総合研究科, 助教 (80625161)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歯根膜 / マラッセ上皮遺残 / 細胞伝達 / 細胞間伝達 / 幹細胞
Research Abstract

The regulatory mechanism of tissue stem cell and its surrounding environment is not clearly revealed. In the present study, the tissue stem cells were shown to be scattered around the root surface. There were Gap junctions between the periodontal ligaments cell to cell, these expression levels were changed in the hypoxia condition. Therefore, we revealed the part of the mechanism in the maintenance and remodeling at the periodontal tissue.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Regulation of CCN1 via the 3'-untranslated region2013

    • Author(s)
      Nakagawa Y, Minato M, Sumiyoshi K, Maeda A, Hara C, Murase Y, Nishida T, Kubota S, Takigawa M
    • Journal Title

      J. Cell Commun Signal

      Volume: 7(3) Pages: 207-17

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gap-junction-mediated communication in human periodontal ligament cells2013

    • Author(s)
      Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
    • Journal Title

      J Dent Res

      Volume: 92(7) Pages: 635-40

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel role of miR-181a in cartilage metabolism2013

    • Author(s)
      Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Abd El Kader T, Nishida T, Ikeda N, Shimo T, Yamashiro T, Takigawa M
    • Journal Title

      J Cell Biochem

      Volume: 114(9) Pages: 2094-100

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gap junction-mediated communication in human periodontal ligament cells2013

    • Author(s)
      Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T and Yamashiro T
    • Journal Title

      JDR

      Volume: 92(7) Issue: 7 Pages: 635-40

    • DOI

      10.1177/0022034513489992

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of CCN1 via the 3’-untranslated region.2013

    • Author(s)
      Nakagawa, Y., Minato, M., Sumiyoshi, K., Maeda, A., Hara, C., Murase, Y., Nishida, T., Kubota, S. and Takigawa, M.:
    • Journal Title

      J. Cell Commun. Signal., 7, 207-217, 2013.

      Volume: 7 Issue: 3 Pages: 207-217

    • DOI

      10.1007/s12079-013-0202-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel role of miR-181a in cartilage metabolism.2013

    • Author(s)
      Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Abd El Kader T, Nishida T, Ikeda N, Shimo T, Yamashiro T, Takigawa M
    • Journal Title

      J Cell Biochem

      Volume: in press Issue: 9 Pages: 2094-100

    • DOI

      10.1002/jcb.24556

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間コミュニケーションの骨代謝へ及ぼす影響2013

    • Author(s)
      加藤龍史, 石原嘉人, 川邉紀章, 住吉久美, 吉川祐介, 福島宏明, 上岡寛, 山本照子, 山城隆
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Gap junction-mediated communication in human periodontal ligament cells2013

    • Author(s)
      Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
    • Organizer
      NIH-Tohoku University-JSPS Symposium
    • Place of Presentation
      Sendai. Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Gap junction-mediated communication in human periodontal ligament cells.2013

    • Author(s)
      Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto
    • Organizer
      NIH-Tohoku University-JSPS Symposium
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間伝達は低酸素環境下において抑制的に調節される2012

    • Author(s)
      加藤龍史, 石原嘉人, 川邉紀章, 住吉久美, 吉川祐介, 今井裕一, 上岡寛, 山本照子, 山城隆
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] イノシトール三リン酸は生きた骨組織中における細胞内カルシウム応答の必須因子である2012

    • Author(s)
      石原嘉人, 菅原康代, 上岡寛, 川邉紀章, 柳田剛志, 住吉久美, 山城隆
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間伝達は低酸素環境下において抑制的に調節される2012

    • Author(s)
      加藤 龍史, 石原 嘉人, 川邉 紀章, 住吉 久美, 吉川 祐介, 今井 裕一, 上岡 寛, 山本 照子, 山城 隆
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report
  • [Presentation] イノシトール三リン酸は生きた骨組織中における細胞内カルシウム応答の必須因子である2012

    • Author(s)
      石原 嘉人, 菅原 康代, 上岡 寛, 川邉 紀章, 柳田 剛志, 住吉 久美, 山城 隆
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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