The role of HIF-1 and BMP-2 in Temporomandibular joint osteoarthritis.
| Project/Area Number |
24792285
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
SHIRAKURA Maya 広島大学, 医歯薬保健学研究院(医), 助教 (70549013)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 軟骨 / 骨 / 代謝 / 低酸素 / 機械刺激 / HIF-1α / BMP-2 / 変形性顎関節症 / 細胞外マトリクス / ＢＭＰ－２ / 機械的刺激 / 骨代謝 |
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| Outline of Final Research Achievements |
Temporomandibular joint osteoarthritis (TMJ-OA) is a complex disease that affects both cartilage and subchondral bone. It is accompanied by loss of extracellular matrix (ECM) and may be affected by Bone Morphogenetic Protein 2 (BMP-2). We analyzed the effect of BMP-2 in both cartilage and subchondral bone in a TMJ-OA animal model that is deficient in biglycan and fibromodulin (DKO) using an explant culture system. As a result, the upregulation of both anabolic and catabolic genes in the WT and DKO TMJs treated with BMP-2 suggests that BMP-2 increases matrix turnover in the condyle and, further, that Bgn/Fmod could have protective roles in regulating this process.
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Report
(4 results)
Research Products
(6 results)
