Elucidation of the mechanism ameloblastin upregulates formation of tooth root, and application to the treatment of root resorption

Research Project

Project/Area Number	24792286
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Hiroshima University
Principal Investigator	HIROSE Naoto 広島大学, 大学院医歯薬保健学研究院, 助教 (50611935)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	蛋白 / 再生医療 / 蛋白質 / 発現抑制 / 国際情報交換
Research Abstract	It was revealed thatameloblastin was related to proliferation of ameloblasts. Its regulatory mechanism was that the protein inhibited p21Cip1 and p27Kip1 which were both negative factors in cell cycle. Additionally, ameloblastin also regulated proliferation of Hertwig's Epithelial cells in apical tooth root. Furthermore, it was suggested that ameloblastin had the function of upregulating calcification in interaction between ameloblasts and odontoblasts.

Report

(3 results)