| Project/Area Number |
24792290
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | The University of Tokushima |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
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| Keywords | D-dopachrome tautomerase / 脂肪細胞 / 転写調節 / AMPK / 脂肪細胞分化 |
|---|
| Research Abstract |
Promoter region of gene encoding D-dopachrome tautomerase (DDT), an adipokine which improves obesity-induced insulin resistance, was found to be located between 200 bp upstream and 23 bp downstream of the first methionine codon. The transcriptional activity of DDT gene was induced by oxidative stress or serum starvation in preadipocytes. Furthermore, cAMP-activated protein kinase (AMPK) was found to be involved in the transcription.
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