| Project/Area Number |
24792291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 歯根吸収 / 矯正的歯の移動 / アレルギー / ロイコトリエン / 破骨細胞 / 骨吸収 / 脂質メディエーター / 骨代謝学 |
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| Outline of Final Research Achievements |
Root resorption is one of the most popular iatrogenic problems during orthodontic tooth movement, while onset mechanisms and progression of root resorption has not been elucidated. In this study, we investigated the mechanisms of allergy-induced root resorption. We used Brown-Norway rats as allergy model, which are known as high IgE producers after sensitization by ovalbumin (OVA). After the sensitization, a stretched closed-coil spring as an orthodontic appliance was placed between the maxillary right first molar and the incisors moving the molar mesially. The expression levels of pro-inflammatory cytokines such as IL-1 and IL-6 and Th17 cytokines were increased in periodontal tissues of OVA-sensitized animals subjected to orthodontic movement, compared with non sensitized rats. Furthermore, the LTB4 level and the mRNA levels of the LTB4 receptors were also increased in OVA-sensitized animals subjected to orthodontic movement.
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