ASL and DTT imaging for brain and stomatognathic network system
| Project/Area Number |
24792292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University (2014-2015)
Nagasaki University (2012-2013) |
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Principal Investigator |
YUKIKO KAMI 九州大学, 歯学研究科(研究院), 助教 (60552023)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MRI / arterial spin labeling / ASL / 咀嚼 / 味覚 |
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| Outline of Final Research Achievements |
The arterial spin labeling (ASL) technique allows noninvasive quantitative assessment of tissue perfusion without the need for contrast agent. We compared the perfusion properties of the parotid glands between patients with SS and those with healthy glands using ASL. We analyzed salivary blood flow (SBF) kinetics of 22 healthy parotid glands from 11 volunteers and 28 parotid glands from 14 SS patients. Base SBFs of the SS glands were significantly higher than those of healthy glands. SBF kinetic profiles of the SS glands also exhibited significantly later SBF peaks and higher SBF increment ratios than the healthy glands. Taken together, these results showed that the SS parotid glands were mostly hyperemic and the SS gland responses to gustatory stimulation were stronger and more prolonged than those of the healthy glands. The ASL may be a promising technique for assessing the diseased salivary gland vascularization of SS patients.
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Report
(5 results)
Research Products
(5 results)
