ASL and DTT imaging for brain and stomatognathic network system

• Project/Area Number: 24792292
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kyushu University (2014-2015); Nagasaki University (2012-2013)
• Principal Investigator: YUKIKO KAMI 九州大学, 歯学研究科(研究院), 助教 (60552023)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: MRI / arterial spin labeling / ASL / 咀嚼 / 味覚

Outline of Final Research Achievements

The arterial spin labeling (ASL) technique allows noninvasive quantitative assessment of tissue perfusion without the need for contrast agent. We compared the perfusion properties of the parotid glands between patients with SS and those with healthy glands using ASL. We analyzed salivary blood flow (SBF) kinetics of 22 healthy parotid glands from 11 volunteers and 28 parotid glands from 14 SS patients. Base SBFs of the SS glands were significantly higher than those of healthy glands. SBF kinetic profiles of the SS glands also exhibited significantly later SBF peaks and higher SBF increment ratios than the healthy glands. Taken together, these results showed that the SS parotid glands were mostly hyperemic and the SS gland responses to gustatory stimulation were stronger and more prolonged than those of the healthy glands. The ASL may be a promising technique for assessing the diseased salivary gland vascularization of SS patients.

Research Products

• [Journal Article] Arterial Spin Labeling Imaging for the Parotid Glands of Patients with Sjögren's Syndrome (2016)
  • Author(s): Kami YN, Sumi M, Takagi Y, Sasaki M, Uetani M, Nakamura T.
  • Journal Title: PLoS One Volume: 11(3) Issue: 3 Pages: e0150680-e0150680
  • DOI: 10.1371/journal.pone.0150680
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 咀嚼がヒト脳機能に及ぼす影響～Arterial Spin Labeling(ASL)を用いた評価～ (2014)
  • Author(s): 加美由紀子, 筑井徹, 吉浦敬, 樋渡昭雄, 西岡真人, 舩津亮平, 小林幸二, 小原真, 本田浩, 吉浦一紀
  • Organizer: 第55回日本歯科放射線学会総会・学術大会
  • Place of Presentation: タワーホール船堀（東京）
  • Year and Date: 2014-06-06 – 2014-06-08
• [Presentation] Arterial Spin Labeling (ASL)を用いた耳下腺機能評価 (2013)
  • Author(s): 加美由紀子、角美佐、中村卓
  • Organizer: 第54回 日本歯科放射線学会学術大会
  • Place of Presentation: 福岡県立ももち文化センター（福岡県）
• [Presentation] Arterial Spin Labeling (ASL)を用いたシェーグレン症候群患者の耳下腺血流評価 (2013)
  • Author(s): 加美由紀子、角美佐、高木幸則、中村卓
  • Organizer: 第18回 日本歯科放射線学会臨床画像大会
  • Place of Presentation: 東京歯科大学水道橋校舎（東京都千代田区）
• [Presentation] 咀嚼と脳機能の関連 ～ＭＲＩを用いた評価～
  • Author(s): 加美由紀子、筑井徹、西岡真人、小林幸次、船津亮平、吉浦敬、徳森謙二、吉浦一紀
  • Organizer: 日本歯科放射線学会第３３回関西・九州合同地方会
  • Place of Presentation: 福岡