| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Sox21 which is a novel mature ameloblast marker was related to the differentiation to terminal ameloblasts from mature ameloblasts. Therefore, The cell polarity of a mature ameloblast disappears by absence of Sox21. For this reason, since a formation of an enamel rod is impeded, the abnormals in a crystal structure and hypomineralization of an enamel rod are triggered. Finally, The defect of Sox21 causes an amelogenesis imperfecta. Moreover, the expression of Sox21 in an ameloblast was regulated by Shh.
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