Novel ameloblast marker Sox21 regulate the differentiation of dental epithelial cells?
Project/Area Number |
24792294
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Tohoku University |
Principal Investigator |
SAITO Kan 東北大学, 大学病院, 助教 (40380852)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | エナメル芽細胞 / エナメル質形成不全 / 発生 |
Outline of Final Research Achievements |
Sox21 which is a novel mature ameloblast marker was related to the differentiation to terminal ameloblasts from mature ameloblasts. Therefore, The cell polarity of a mature ameloblast disappears by absence of Sox21. For this reason, since a formation of an enamel rod is impeded, the abnormals in a crystal structure and hypomineralization of an enamel rod are triggered. Finally, The defect of Sox21 causes an amelogenesis imperfecta. Moreover, the expression of Sox21 in an ameloblast was regulated by Shh.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Interaction between Fibronectin and β1 Integrin is Essential for Tooth Development.2015
Author(s)
Saito, K., Fukumoto, E., Yamada, A., Yuasa, K., Yoshizaki, K., Iwamoto, T., Saito, M., Nakamura, T., and Fukumoto, S.
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Journal Title
PLOS one
Volume: 10(4)
Issue: 4
Pages: 1-12
DOI
NAID
Related Report
Peer Reviewed / Open Access
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