• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The analysis of the bone remodeling control mechanism by transcription factor IRF-4

Research Project

Project/Area Number 24792297
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

KOHARA Haruka  長崎大学, 大学病院, 医員 (70623825)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords歯学
Research Abstract

Interferon (IFN) is induced by interferon regulatory factors (IRFs) which act as a transcription factor. This factor is related to immunoreactions. Recently IRF-8, which is one of the IRFs, has been reported to negatively regulate the proliferation of osteoclast precursors induced by macrophage colony-stimulating factor (M-CSF) and ligand for receptor activator of nuclear factor kappa B (RANKL). In this study, we investigated the effects of IRF-4 on RANKL- (or TNF-alpha-) induced osteoclastogenesis.
Bone marrow cells from mice were cultured with M-CSF and RANKL. During osteoclastogenesis, the expression level of NFATc1 and IRF-4 mRNA were increased significantly. Moreover, the same dynamic state was shown also in osteoclastogenesis under M-CSF and TNF-alpha existence. These results suggest that IRF-4 may involve the regulation of osteoclast precursors.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (10 results)

  • [Journal Article] Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane2014

    • Author(s)
      Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T
    • Journal Title

      The Scientific World Journal

      Volume: 2014 Pages: 1-7

    • NAID

      120006986701

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane2014

    • Author(s)
      Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T
    • Journal Title

      Scientific World Journal

      Volume: 19 Pages: 1-7

    • DOI

      10.1155/2014/617032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo2013

    • Author(s)
      Kitaura H, Kimura K, Ishida M, Kohara H, Yoshimatsu M, Takano-Yamamoto T
    • Journal Title

      Clinical and Developmental Immunology

      Volume: 2013 Pages: 1-8

    • NAID

      120006986213

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunological reaction in TNF- α-mediated osteoclast formation and bone resorption in vitro and in vivo2013

    • Author(s)
      Kitaura H, Kimura K, Ishida M, Kohara H, Yoshimatsu M, Takano-Yamamoto T
    • Journal Title

      Clin Dev Immunol

      Volume: 2013 Pages: 1-8

    • DOI

      10.1155/2013/181849

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice2012

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
    • Journal Title

      Archives of Oral Biology

      Volume: 57(1) Pages: 36-43

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory Effect of Interferon-γ on Experimental Tooth Movement in Mice2012

    • Author(s)
      Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
    • Journal Title

      Journal of Interferon & Cytokine Research

      Volume: 32(9) Pages: 426-431

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of IFN-γ on experimental toothmovement in mice.2012

    • Author(s)
      Kohara, H., Kitaura, H., Yoshimatsu, M., Fujimura, Y., Morita, Y., Eguchi, T., Yoshida, N.
    • Journal Title

      J. Interferon Cytokine. Res.

      Volume: 32 Issue: 9 Pages: 426-431

    • DOI

      10.1089/jir.2011.0124

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice2012

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimuar Y, Kohara H, Morita Y, Eguchi T, Yoshida N
    • Journal Title

      Arch Oral Biol

      Volume: 57 Issue: 1 Pages: 36-43

    • DOI

      10.1016/j.archoralbio.2011.07.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 小腸上皮 ATP 文会系によるカルシウム吸収調節機序の検討2014

    • Author(s)
      小原悠, 増山律子
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 小腸上皮ATP分解系によるカルシウム吸収調節機序の検討2014

    • Author(s)
      小原 悠、増山律子
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 矯正学的歯の移動時におこる歯根吸収に対する IFN-γ の影響2013

    • Author(s)
      小原悠, 北浦英樹, 吉松昌子, 藤村裕治, 森田幸子, 吉田教明
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] 矯正学的歯の移動時におこる歯根吸収に対するIFN-γの作用について2013

    • Author(s)
      小原悠、北浦英樹、吉松昌子、藤村裕治、森田幸子、吉田教明
    • Organizer
      第72会日本矯正歯科学会大会
    • Place of Presentation
      長野県松本文化会館(松本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IFN-γ inhibits mechanical stress-induced osteoclastogenesis and bone resorption2012

    • Author(s)
      Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] メカニカルストレスに対する歯根周囲組織における IFN-γ の影響2012

    • Author(s)
      小原悠, 北浦英樹, 吉松昌子, 藤村裕治, 森田幸子, 吉田教明
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report
  • [Presentation] メカニカルストレスに対する IFN-γ の発現およびその影響2012

    • Author(s)
      小原悠, 北浦英樹, 吉松昌子, 森田幸子, 藤村裕治
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      新宿
    • Related Report
      2013 Final Research Report
  • [Presentation] IFN-γ inhibits mechanical stress-induced osteoclastogenesis and bone resorption.2012

    • Author(s)
      Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
    • Organizer
      2012 Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Minneapolis, MN, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] メカニカルストレスに対するIFN-γの発現およびその影響.2012

    • Author(s)
      小原悠,北浦英樹,吉松昌子,森田幸子,藤村裕治
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      新宿
    • Related Report
      2012 Research-status Report
  • [Presentation] メカニカルストレスに対する歯根周囲組織におけるINF-γの影響2012

    • Author(s)
      小原 悠,北浦英樹,吉松昌子,藤村裕治,森田幸子,吉田教明
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi