| Project/Area Number |
24792311
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 骨形成 / 矯正治療 / 加齢 / 歯根膜細胞 / 間葉系幹細胞 / メカニカルストレス |
|---|
| Research Abstract |
It is shown that the alveolar crestal bone loss is high in adults than in young patients during orthodontic treatment. We suspect that the ability of bone remodeling is changed by age. Periodontal ligament tissue (PDL) retains the potential to differentiate into the cells that constitute the PDL. Also, it is reported that the human PDL-derived mesenchymal stem cells (PDLSC) were isolated from normal teeth. In this study we investigate the proportion of PDLSC in cultured PDL cells obtained from various age, and examined the response of mechanical stress. The results indicate that the proportion has not correlation to the donor age. Then the expression of Bone morphogenetic protein-2 was increased by the application of mechanical stress, also the expression of cyclooxygenase-2, which regulates the PGE2 was increased by the application of strong MS. It indicates MS affect the expressions of bone remodeling factors in PDLSC.
|
