Effect of epigenetics and the expression of miRNAs on occlusal activity during the postnatal development of masticatory and tongue muscle
| Project/Area Number |
24792313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 咬合の欠如 / 咀嚼筋 / 生後発達 / エピジェネティクス / miRNA / 歯学 / 舌筋 |
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| Research Abstract |
Epigenetics involves genetic control by mechanisms other than DNA sequence. These epigenetic mechanisms have ability to switch on or off various important genes.MicroRNAs (miRNAs) are single-stranded 19-25 nucleotide-long RNAs and have an important role in post-transcriptional gene expression.
In this study,the regulatory pathway of miR-1 plays a more prominent role during postnatal development in the masseter muscle than in the gastrocnemius muscle, whereas the regulatory pathway of miR-133a plays a more prominent role in gastrocnemius muscle than in the masseter muscle.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Role of occlusion in mouse masseter muscle acetylcholine receptor clustering2013
Author(s)
MORI, M., NARIYAMA, M., ABO, T., HIRAI, S., OGAWA, T., HAMADA, Y., YAMANE, A. and ASADA, Y.
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Journal Title
J. Dent. Res.
Volume: 92
Issue: 4
Pages: 352-357
DOI
Related Report
Peer Reviewed
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