| Project/Area Number |
24792318
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Muenke症候群 / 線維芽細胞成長因子 / 顎関節 / Indian hedgehog / FGFR3 / FGFR3(P244R)変異マウス / 下顎頭軟骨 / Muenke syndrome / bFGF / ヘパラン硫酸 |
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| Research Abstract |
Muenke syndrome is characterized by various craniofacial deformities and is caused by an autosomal dominant activating mutation in fibroblast growth factor receptor 3. Here we determined whether the mutation affects temporomandibular joint development and growth using mice carrying a corresponding mutation. In situ hybridization showed that Fgfr3 is normally expressed in condylar chondroprogenitors and maturing chondrocytes that expressed also the Indian hedgehog receptor and transcriptional target Patched 1.In Fgfr3mutants, the condylar growth plates were disorganized and displayed reduced levels of Ihh expression, H4C-positive proliferating chonWe also observed disrupted development of TMJ articular eminence glenoid fossa.droprogenitors, and collagens type II- and type X-expressing chondrocytes. Our data indicate that the activating FgfR3mutation disturbs normal TMJ developmental processes likely by reducing hedgehog signaling and endochondral ossification.
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