Analysis of microbiota and its function associated with peri-implantitis using next generation sequencing technology
| Project/Area Number |
24792321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKEUCHI Yasuo 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (60396968)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWA Ichiro 東京医科歯科大学, 大学院・医歯(薬)学総合研究科, 教授 (70294113)
KOYANAGI Tatsuro 東京医科歯科大学, 歯学部附属病院, 医員 (70632173)
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| Research Collaborator |
MARUYAMA Noriko 東京医科歯科大学, 大学院・医歯(薬)学総合研究科, 大学院生
SHIBA Takahiko 東京医科歯科大学, 大学院・医歯(薬)学総合研究科, 大学院生
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インプラント周囲炎 / 歯周病原細菌 / 次世代シークエンシング / polymicrobial disease / トランスクリプトーム / インプラント / 歯周炎 / 細菌 |
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| Research Abstract |
As the results of comprehensive analysis of microbiota in peri-implantitis and periodontitis, the core microbial species represented peri-implantitis were differed with those of periodontitis, although there were no significant differences in species richness and evenness. Peri-implantitis is a polymicrobial disease, and its biofilm was composed of various microbial species. While, the species that were abundant in biofilm was not necessarily active in the diseased sites. Expression of functional genes related with virulence, disease and defense, and stress response were elevated in the microbiota of peri-implantitis than in periodontitis.
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Report
(3 results)
Research Products
(15 results)
