| Project/Area Number |
24792325
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯周病 / 糖尿病 / 高血糖 / 歯肉上皮細胞 / 自然免疫 / 歯肉上皮 |
|---|
| Research Abstract |
Both diabetes and periodontal disease are chronic disease and as risk factors mutually that have an influence on pathologic complexity, the difficulty of the treatment. However, the details of the mechanism of the relation of these diseases are not well known enough because periodontal disease is an infectious disease, and diabetes is a metabolism abnormal disease. In this study, we investigated the effect of diabetic condition on human gingival epithelial cells.
The result of research revealed that high glucose condition induced the expression of inflammatory cytokine (IL-8 etc.) and Toll like receptor 2 elevating in vitro. In addition, we found that oxidative stress was involved in these high glucose effects. These findings may reveal the molecular mechanism of diabetic patients having periodontal disease.
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