Development of photosensitizer with urea-Establishment of periodontal treatment combined with Er:YAG laser.

• Project/Area Number: 24792329
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontal dentistry
• Research Institution: Hiroshima University
• Principal Investigator: MINEOKA Akane 広島大学, 大学病院, 助教 (00452623)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: レーザー / 歯周病 / LPS / 光感受性物質 / ＬＰＳ

Research Abstract

In recent years, there has been growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this study was to acquire an effective Er:YAG laser treatment with photosensitizer and evaluate the effects of antimicrobial photodynamic therapy(aPDT) with urea-containing reagent as photosensitizer for periodontal treatment.
It was comfirmed that the concentration of urea the most effectively involved in tarter removement was 5% urea.With urea-containing reagent application, the number of P.gingivalis decreased with increasing Er:YAG laser irradiation time in vitro. Laser with photosensitizer reagent group had a higher LPS elimination efficiency with increasing energy density,there was no significant difference between laser group and laser with photosensitizer reagent group though.