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Elucidation of the mechanism of BDNF-induced suppression of gingival epithelium invasion in the process of periodontal tissue regeneration

Research Project

Project/Area Number 24792330
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontal dentistry
Research InstitutionHiroshima University

Principal Investigator

MATSUDA Shinji  広島大学, 大学病院, 病院助教 (30611321)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsBDNF / 歯周組織再生 / 歯肉上皮細胞 / アポトーシス
Research Abstract

Brain-derived neurotrophic factor (BDNF) did not affect proliferation of human gingival epithelial cells (HGEC) while BDNF enhanced the proliferation of human periodontal ligament cells (HPL cells). Furthermore BDNF at high concentration induced apoptosis of HGEC. BDNF-induced apoptosis was activated by caspase-3 through p75 receptor and JNK signaling pathway. These findings suggested that BDNF can activate not trkB-ERK but p75-JNK signaling cascade, which do not affect gingival epithelial cells proliferation.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results)

  • [Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade2014

    • Author(s)
      Kajiya M, Takeshita K, Kittaka M, Matsuda S, Ouhara K, Takeda K, Takata T, Kitagawa M, Fujita T, Shiba H, Kurihara H
    • Journal Title

      Int Immunopharmacol

      Volume: 19(2) Pages: 245-52

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.2014

    • Author(s)
      Kajiya M, Takeshita K, Kittaka M, Matsuda S, Ouhara K, Takeda K, Takata T, Kitagawa M, Fujita T, Shiba H, Kurihara H
    • Journal Title

      International Immunopharmacology

      Volume: 19 Pages: 245-252

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans2013

    • Author(s)
      Miyagawa T, Fujita T, Ouhara K, Matsuda S, Kajiya M, Hayashida K, Imai H, Yoshimoto T, Iwata T, Shiba H, Abiko Y, Kurihara H
    • Journal Title

      Int Immunopharmacol

      Volume: 15(2) Pages: 340-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans.2013

    • Author(s)
      Miyagawa T, Fujita T, Ouhara K, Matsuda S, Kajiya M, Hayashida K, Imai H, Yoshimoto T, Iwata T, Shiba H, Abiko Y, Kurihara H.
    • Journal Title

      International Immunopharmacology

      Volume: 15 Pages: 340-347

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans.2013

    • Author(s)
      Miyagawa T
    • Journal Title

      Int Immunopharmacol

      Volume: 15 Issue: 2 Pages: 340-347

    • DOI

      10.1016/j.intimp.2012.12.011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 脳由来神経栄養因子はヒト歯肉上皮細胞のアポトーシスカスケードを活性化する2013

    • Author(s)
      柏井桂, 加治屋幹人, 藤田剛, 松田真司, 武田克浩, 柴秀樹, 栗原英見
    • Organizer
      日本歯科保存学会 2013年度秋季学術大会(第139回)
    • Place of Presentation
      秋田
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳由来神経栄養因子はヒト歯肉上皮細胞のアポトーシスカスケードを活性化する2013

    • Author(s)
      柏井 桂
    • Organizer
      日本歯科保存学会2013年度秋季学術大会(第139回)
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳由来神経栄養因子のヒト歯肉上皮細胞に与える影響2012

    • Author(s)
      柏井桂, 加治屋幹人, 藤田剛, 松田真司, 武田克浩, 柴秀樹, 栗原英見
    • Organizer
      第137回日本歯科保存学会学術大会(秋季)
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of BDNF on human gingival epithelial cells2012

    • Author(s)
      K.Kashiwai, S.Matsuda, T.Fujita, M.Kajiya, K.Takeda, H.Shiba, H.Kurihara
    • Organizer
      The American Academy of Periodontology
    • Place of Presentation
      ロサンゼルス, アメリカ
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳由来神経栄養因子のヒト歯肉上皮細胞に与える影響2012

    • Author(s)
      柏井桂
    • Organizer
      第137回日本歯科保存学会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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