| Project/Area Number |
24792333
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
BANDO Mika 徳島大学, 大学病院, 助教 (10510000)
|
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 終末糖化産物 / 歯肉線維芽細胞 / 酸化ストレス |
|---|
| Research Abstract |
The aim of this study is investigation of diabetes-associated periodontitis pathogenesis from a point of oxidative stress, and utilization of antioxidative stress mechanism as new treatment. Advanced glycation end-product (AGE) and periodontopathic factor (P-LPS) increased expressions of AGE receptor, oxidative stress markers, antioxidative enzyme and inflammatory cytokine in human gingival fibroblasts. Inhibitors of MAPK pathway inhibited AGE-induced cytokine expression. KGF increased expression of antioxidative enzyme . These findigs suggest that AGE and P-LPS make a diabetes-associated periodontitis pathogenesis worse by production oxidative stress and inflammatory cytokine. KGF may enhance antioxidative stress mechanism.
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