| Project/Area Number |
24792339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ウナギレクチン / 歯周病原細菌 / 内毒素 / 炎症性サイトカイン / バイオフィルム |
|---|
| Research Abstract |
Periodotitis is infectious disease induced by periodontal pathogens. Many natural antibacterial substances have been reported as useful agents in the prevention and treatment of periodontal disease. We have reported that galectin AJL-1 found in skin mucus of eel possessed some useful abilities against periodontal pathogen.
AJL-2 is a lectin, also found in skin mucus of eel, and we focused it in this study. We investigated the inhibitory effects of AJL-2 on the endotoxin-mediated inflammatory cytokine-inducing activities of periodontopathic bacteria, and on the biofilm formation by those pathogens.
Then, AJL-2 inhibited inducing of the cytokine, but it showed no inhibitory effect on the biofilm formation as well as AJL-1. Further investigations about the difference of mechanism between these two substances are required to develop a new agent for more effective periodontal therapy.
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