The influence of diabetes on inflammatory bone metabolism
| Project/Area Number |
24792342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 炎症性骨代謝 / 糖尿病 / 歯周病 / 骨芽細胞 / 破骨細胞 / 終末糖化産物 / 歯周免疫機能学 |
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| Outline of Final Research Achievements |
It is not yet fully understood for a detailed mechanism for the impact on the local periodontal disease from diabetes. In this study, it has been found that low concentrations of advanced glycation end products (AGE) promotes the differentiation of osteoblasts, and RANKL-induced differentiation of osteoclasts. Meanwhile, the high concentration of AGE resulted in cytotoxicity to the osteoclast precursor cells. From the results of this study, it is considered that high concentration of AGE in diabetic patients direct high rotation type of bone metabolism. This has suggested the effect on local periodontitis by diabetes, it is believed to be representative of one of the relevant mechanisms of both diseases.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Periodontitis-activated monocytes/macrophages cause aortic inflammation2014
Author(s)
Miyajima S, Naruse K, Kobayashi Y, Nakamura N, Nishikawa T, Adachi K, Suzuki Y, Kikuchi T, Mitani A, Mizutani M, Ohno N, Noguchi T, Matsubara T
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Journal Title
Sci Rep
Volume: 4
Issue: 1
Pages: 5171-5171
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Inflammatory bone loss in experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in IL-1Ra knockout mice.2014
Author(s)
Izawa A, Ishihara Y, Mizutani H, Kobayashi S, Goto H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Sugita Y, Kubo K, Kamei H, Kikuchi T, Mitani A, Hayashi J, Nishihara T, Maeda H, Noguchi T.
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Journal Title
Infect Immun
Volume: 82
Issue: 5
Pages: 1904-1913
DOI
Related Report
Peer Reviewed
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[Presentation] 歯周炎によって活性化された単核球が大動脈の炎症を惹起する機序の検討2014
Author(s)
宮島真一, 成瀬桂子, 中村信久, 西川 徹, 足立 圭, 鈴木佑基, 水谷 誠, 菊池 毅, 野口俊英, 大野紀和, 松原達昭, 三谷章雄
Organizer
第57回日本歯周病学会秋季学術大会
Place of Presentation
神戸
Year and Date
2014-10-19
Related Report
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[Presentation] GIPは歯周炎を抑制する2014
Author(s)
鈴木佑基, 成瀬桂子, 小林泰子, 中村信久, 西川 徹, 宮島真一, 足立 圭 , 水谷 誠, 菊池 毅, 宮澤健, 月山克史, 山田祐一郎, 後藤滋巳, 大野紀和, 三谷章雄, 松原達昭
Organizer
第57回日本糖尿病合併症学会
Place of Presentation
東京
Year and Date
2014-10-03
Related Report
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[Presentation] GIPは歯周炎を抑制する2014
Author(s)
鈴木佑基, 成瀬桂子, 小林泰子, 中村信久, 西川 徹, 宮島真一, 足立 圭, 水谷 誠, 菊池 毅, 宮澤健, 月山克史, 山田祐一郎, 後藤滋巳, 大野紀和, 三谷章雄, 松原達昭
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪
Year and Date
2014-05-22
Related Report
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[Presentation] Impact of the activation of poly (ADP-ribose) polymerase on the periodontitis in diabetic rats2013
Author(s)
Adachi K, Naruse K, Kobayashi Y, Nakamura N, Nishikawa T, Miyajima S, Suzuki Y, Mizutani M, Kikuchi T, Ohno N, Noguchi T, Matsubara T
Organizer
The 73rd Scientific Sessions, American Diabetes Association
Place of Presentation
Chicago
Related Report
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