| Project/Area Number |
24792344
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Fujita Health University |
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Principal Investigator |
TSUGE Shinya 藤田保健衛生大学, 医学部, 客員講師 (30469035)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 酵素抗原法 / AlphaScreen / コムギ無細胞タンパク質合成系 / 抗体産生細胞 / Porphyromonas gingivalis / 歯周病 / コムギ無細胞蛋白質合成系 |
|---|
| Research Abstract |
Histologically, the gingival tissue in periodontitis shows dense infiltration of plasma cells. However, antigens recognized by antibodies secreted from the immunocytes remain unknown. Porphyromonas gingivalis (Pg) is the major pathogen of periodontitis. Therefore, it is possible that these immunocytes produce antibodies to antigens of Pg. In the present research, we attempted to demonstrate the Pg-specific antibody producing cells in the gingival tissues of periodontitis with the AlphaScreen method and the enzyme-labeled antigen method. As a result, the plasma cells producing antibodies specific to Pg antigens were detected in the diseased gingiva. This finding suggests inflammatory reactions to Pg is involved in periodontitis.
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