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Foundation of infection control strategy for implantitis with nanonetwork structure

Research Project

Project/Area Number 24792345
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontal dentistry
Research InstitutionOsaka Dental University

Principal Investigator

TAGUCHI Yoichiro  大阪歯科大学, 歯学部, 講師 (60434792)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsインプラント周囲炎 / 表面性状 / 硬組織分化 / 歯周病 / ナノ構造 / 硬組織分化誘導
Research Abstract

Peri-implantitis can result in failure of implant osseointegration. Lipopolysaccharides (LPS) act as a chronic stimulus, maintaining peri-implant inflammation and thereby worsening the prognosis for implant osseointegration. The purpose of this study was to determine the effect of Porphyromonas gingivalis (P. gingivalis) LPS on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) on a nanonetwork titanium surface.
Titanium disks treated with 10 M NaOH solution and untreated control disks were incubated with BMMSCs and then exposed to P. gingivalis LPS. The BMMSCs on the nanonetwork titanium surface with nanonetwork structure had significantly higher cell proliferation and cell differentiation when exposed to P. gingivalis LPS at different concentrations than cells on the control surfaces.
The nanonetwork titanium surface had better endotoxin tolerance under P. gingivalis LPS exposure than non-modified surfaces.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (15 results)

  • [Journal Article] Osteogenic activity of titanium surfaces with nanonetwork structures2014

    • Author(s)
      Xing H, Komasa S, Taguchi Y, Sekino T, Okazaki J
    • Journal Title

      Int J Nanomedicine

      Volume: 9 Pages: 1741-1755

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rat endothelial cell attachment, behavior and gene expression on NaOH-treated titanium surfaces2014

    • Author(s)
      Nakano Y, Komasa S, Taguchi Y, Sekino T, Okazaki J
    • Journal Title

      J Oral Tissue Engin

      Volume: 11 Pages: 189-200

    • NAID

      130004941111

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell differentiation on nanoscale features of a titanium surface : effect of deposition time in NaOH solution2014

    • Author(s)
      Tomoko Fujino, Yoichiro Taguchi, Satoshi Komasa, Tohru Sekino, Masahiro Tanaka
    • Journal Title

      J Hard Tissue Biol

      Volume: 23 Pages: 63-70

    • NAID

      130004480639

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis LPS inhibits osteoblastaic differentiation and promotes pro-inflammatory cytokine production in human periodontla ligamnet stem cells2014

    • Author(s)
      Hirohito Kato, Yoichiro Taguchi, Kazuya Tominaga, Makoto Umeda, Akio Tanaka
    • Journal Title

      Arch Oral Biol

      Volume: 59 Issue: 2 Pages: 167-175

    • DOI

      10.1016/j.archoralbio.2013.11.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteogenic activity of titanium surfaces with nanonetwork structures2014

    • Author(s)
      H. Xing, S. Komasa, Y. Taguchi, T. Sekino, and J. Okazaki
    • Journal Title

      Int. J. Nanomed.

      Volume: 9 Pages: 1741-1755

    • DOI

      10.2147/ijn.s58502

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioactivity of Nanostructure on Titanium Surface Modified by Chemical Processing at Room Temperature2012

    • Author(s)
      Satoshi Komasa, Yoichiro Taguchi, Hisataka Nishida, Masahiro Tanaka and Takayoshi Kawazoe
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 56 Pages: 170-177

    • NAID

      130004546649

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ナノ構造を用いた最近のインプラントフィクスチャー表面への細胞接着における基盤構築―各種顕微鏡からのアプローチ―2012

    • Author(s)
      梅田誠,田口洋一郎
    • Journal Title

      顕微鏡

      Volume: 47 Pages: 223-227

    • NAID

      10031144743

    • Related Report
      2012 Research-status Report
  • [Presentation] Initial adhesion on nanoscale features of the titanium surface : effects of deposition time in NaOH solution2013

    • Author(s)
      Yoichiro Taguchi
    • Organizer
      European Association for Osseointegration (EAO) 22nd Annual Scientific Meeting
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2013 Final Research Report
  • [Presentation] 純チタン金属の濃アルカリ溶液への浸漬時間の変化がインプラント周囲組織の硬組織形成に与える影響について2013

    • Author(s)
      小正 聡, 田口 洋一郎, 楠本 哲次, 西崎宏, 岡崎 定司
    • Organizer
      第43回日本口腔インプラント学会年次学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Bioactivity of nanostructure on titanium surface modified by chemical processing2013

    • Author(s)
      Komasa S, Taguchi Y, Nishida H, Nakano Y, Kusumoto T, Takeda S, Tanaka M, Okazaki J
    • Organizer
      International Association for Dental Research 2013 annual meeting
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔機能の早期付与および長期維持のためのインプラント表面ナノ構造制御2012

    • Author(s)
      小正 聡, 田口 洋一郎, 西田 尚敬, 藤野智子, 中野 蓉子, 楠本 哲次, 西崎 宏, 田中 昌博, 岡崎 定司
    • Organizer
      日本口腔リハビリテーション学会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノシート構造を析出した純チタン金属表面の硬組織分化誘導能に与える影響について2012

    • Author(s)
      邢 鶴琳, 小正 聡, 田口 洋一郎, 西田尚敬, 中野 蓉子, 藤野 智子, 楠本 哲次, 田中 昌博, 梅田 誠, 岡崎 定司
    • Organizer
      第16回日本顎顔面インプラント学会
    • Place of Presentation
      北九州市
    • Related Report
      2013 Final Research Report
  • [Presentation] Initial biocompatibility of titanium nanostructure surface modified by new method2012

    • Author(s)
      Taguchi Y, Komasa S, Nishida H, Kusumoto T, Takeda S, Yamamoto K, Tanaka M. Okazaki J, Tanaka A, Umeda M
    • Organizer
      European Association for Osseointegration (EAO) 20th Anniversary Meeting
    • Place of Presentation
      Copenhargen, Denmark
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノ構造制御したチタンQCMセンサの表面解析2012

    • Author(s)
      小正 聡, 田口 洋一郎, 橋本 典也, 楠本哲次, 岡崎 定司
    • Organizer
      第42回日本口腔インプラント学会年次学術大会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノレベルでの構造制御による純チタン表面の初期接着能の向上2012

    • Author(s)
      楠本 哲次, 田口 洋一郎, 藤野 智子, 武田 昭二, 田中 昌博
    • Organizer
      第42回日本口腔インプラント学会年次学術大会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of modified titanium surface with nanostructure on initial adhesion2012

    • Author(s)
      Fujino T, Taguchi Y, Komasa S, Nishida H, Takeda S, Kusumoto T, Umeda M, Tanaka A, Kawazoe T
    • Organizer
      2012 Sino-Japan Dental Conference
    • Place of Presentation
      Chengdu, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Bioactivity of titanium nanostructure surface modified by chemical processing at room temperature2012

    • Author(s)
      Komasa S, Taguchi Y, Nishida H, Fujino T, Kusumoto T, Takeda S, Tanaka M, Kawazoe T
    • Organizer
      2012 Sino-Japan Dental Conference
    • Place of Presentation
      Chengdu, China
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規ナノ構造を析出させたチタン表面への細胞の初期接着に与える影響2012

    • Author(s)
      田口洋一郎
    • Organizer
      日本歯周病学会第55回春季学術大会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] チタン合金表面上に析出させたナノシート構造が細胞の硬組織分化誘導に与える影響2012

    • Author(s)
      藤野智子,田口洋一郎,小正聡,西田尚敬,楠本哲次,武田昭二,田中昌博
    • Organizer
      日本補綴歯科学会 平成24年度学術大会
    • Place of Presentation
      神奈川県民ホール
    • Related Report
      2012 Research-status Report
  • [Presentation] ナノレベルでの構造制御による純チタン表面の初期接着能の向上2012

    • Author(s)
      楠本哲次, 田口洋一郎, 藤野智子, 武田昭二, 田中昌博
    • Organizer
      日本口腔インプラント学会第42回年次学術大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] ナノ構造制御したチタンQCMセンサの表面解析2012

    • Author(s)
      小正聡, 田口洋一郎, 橋本典也, 楠本哲次, 岡崎定司
    • Organizer
      日本口腔インプラント学会第42回年次学術大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Initial biocompatibility of titanium nanostructure surface modified by new method.2012

    • Author(s)
      Yoichiro Taguchi, Satoshi Komasa, Hisataka Nishida, Tetsuji Kusumoto, Shoji Takeda, Kazuyo Yamamoto, Masahiro Tanaka, Joji Okazaki, Akio Tanaka, Makoto Umeda
    • Organizer
      European Association of Osseointegration Annual Meeting
    • Place of Presentation
      コペンハーゲン
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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