Research Project
Grant-in-Aid for Young Scientists (B)
Peri-implantitis can result in failure of implant osseointegration. Lipopolysaccharides (LPS) act as a chronic stimulus, maintaining peri-implant inflammation and thereby worsening the prognosis for implant osseointegration. The purpose of this study was to determine the effect of Porphyromonas gingivalis (P. gingivalis) LPS on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) on a nanonetwork titanium surface.Titanium disks treated with 10 M NaOH solution and untreated control disks were incubated with BMMSCs and then exposed to P. gingivalis LPS. The BMMSCs on the nanonetwork titanium surface with nanonetwork structure had significantly higher cell proliferation and cell differentiation when exposed to P. gingivalis LPS at different concentrations than cells on the control surfaces.The nanonetwork titanium surface had better endotoxin tolerance under P. gingivalis LPS exposure than non-modified surfaces.
All 2014 2013 2012
All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (15 results)
Int J Nanomedicine
Volume: 9 Pages: 1741-1755
J Oral Tissue Engin
Volume: 11 Pages: 189-200
130004941111
J Hard Tissue Biol
Volume: 23 Pages: 63-70
130004480639
Arch Oral Biol
Volume: 59 Issue: 2 Pages: 167-175
10.1016/j.archoralbio.2013.11.008
Int. J. Nanomed.
10.2147/ijn.s58502
Journal of Prosthodontic Research
Volume: 56 Pages: 170-177
130004546649
顕微鏡
Volume: 47 Pages: 223-227
10031144743
