| Project/Area Number |
24792368
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NUMABE Yukihiro 日本歯科大学, 生命歯学部, 教授 (90198557)
MURAKASHI Etsuko 日本歯科大学, 生命歯学部, 講師 (40409222)
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| Research Collaborator |
OKUBO Misa
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周病 / LED / 歯周病原細菌 / 歯肉線維芽細胞 / LED光 / Porphyromonas gingivalis / 白色LED / 歯周疾患 / Light Emitting Diode |
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| Outline of Final Research Achievements |
Our study was aimed at building a foundation for safe and effective means to prevent periodontal diseases using light-emitting diode (LED) light, which is commonly used in daily living.
We found that irradiation with blue LED light alone or in combination with white LED light and a photosensitizer was capable of killing bacteria that cause periodontal disease. We also tested growth of human gingival fibroblasts irradiated with LED light of varying wavelengths, and found that the cell growth rate was reduced by irradiation with high-power blue LED light, while red LED light did not affect the cell growth.
These results suggested that LED light have an effect on killing periodontal bacteria, but optimal irradiation conditions should be sought to address the safety to irradiated surrounding periodontal tissues.
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