| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Outline of Final Research Achievements |
In oral regenerative medicine, such as clinical application of iPS cells, infection control is of the utmost importance in order to maintain the healthy oral environmental balance. In recent years, electrolyzed saline solutions are gaining interests among the medical and dental professionals for their anti-bacterial potentials in shortest possible application time. In the present study, some reactive oxygen species (ROS) based electrolyzed saline solutions containing hypochlorous acid (HClO); also known as super-oxidized water (SOW) have been examined for their anti-bacterial effects, potency of biofilm penetration and cytotoxicity. Results have indicated that SOW containing 125 (~145) mg/L active chlorine and 6.8 pH value can be effective enough to control oral pathogens. In addition, it was understood that this kind of highly purified SOW might be useful in oral regenerative medicine as it showed very low level of cytotoxicity on KB cells derived from pharyngeal mucosal epithelium.
|
