| Project/Area Number |
24800003
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Tohoku University |
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Principal Investigator |
HORIE Sachiko 東北大学, 加齢医学研究所, 研究支援者 (90451640)
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| Research Collaborator |
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 癌 / Vasohibin / 遺伝子 / ナノ・マイクロバブル / 超音波 / がん / 血管新生 / 遺伝子導入 |
|---|
| Research Abstract |
Vasohibin-1 (VASH1) is an angiogenesis inhibitor. There are two transcripts of VASH1: one is the full length VASH1A and the other is splicing variant VASH1B. In this study, the anti-antitumor effects of VASH1A and VASH1B have been examined with a mouse solid tumor model using a tissue-specific gene delivery method using nano/microbubbels and ultrasound. Both VASH1A and VASH1B inhibited tumor growth exhibiting anti-angiogenic activity. However, more importantly, VASH1A stabilized neovessels while VASH1B pruned neovessels.
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