Analysis of functional RNAs in the blood streams of pancreatic cancer patients

• Project/Area Number: 24800006
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Tumor diagnosis
• Research Institution: University of Tsukuba
• Principal Investigator: ENOMOTO Tsuyoshi 筑波大学, 医学医療系, 講師 (10628762)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 膵癌 / エクソソーム / micro RNA / 腫瘍診断学 / アンチセンスRNA / 癌

Research Abstract

Pancreatic cancer is one of the most miserable cancers and the radical treatment is curative resection. To improve the prognosis of pancreatic cancer is to diagnosis in early stage. Micro RNAs are incorporated in exosomes from cancer into blood. We analyzed blood serum from pancreatic cancer patients and healthy volunteers. We collected exosomal micro RNAs and performed microarray analysis. Most of the micro RNAs were down regulated in pancreatic cancer patients.