Systems biology analysis of neuronal network that controls salt chemotaxis of C. elegans

• Project/Area Number: 24800014
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: TOYOSHIMA Yu 東京大学, 理学(系)研究科(研究院), 助教 (10632341)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経情報処理 / システム生物学 / ライブイメージング / モデル化とシミュレーション / 線虫

Research Abstract

The nematode C. elegans shows salt chemotaxis. The animals sense gradient of salt concentration through temporal responses of sensory neurons, and they use two different behavioral mechanisms for the gradient in normal and tangential directions. Our improved quantitative imaging systems revealed that the temporal responses of sensory neurons contain information of gradient in both directions. Analyzing mathematical model showed that the extraction of information of gradient in normal direction is required to the one of the two behavioral mechanisms. These results suggest that downstream neurons or neuronal network will extract the information of gradient direction.

Research Products

• [Journal Article] Automated detection and tracking of many cells by using 4D live-cell imaging data (2014)
  • Author(s): Terumasa Tokunaga, Osamu Hirose, Shotaro Kawaguchi, Yu Toyoshima, Takayuki Teramoto, Hisaki Ikebata, Sayuri Kuge, Takeshi Ishihara, Yuichi Iino, and Ryo Yoshida
  • Journal Title: Bioinformatics Volume: (in press)
  • Peer Reviewed
• [Journal Article] Automated detection and tracking of many cells by using 4D live-cell imaging data (2014)
  • Author(s): Terumasa Tokunaga, Osamu Hirose, Shotaro Kawaguchi, Yu Toyoshima, Takayuki Teramoto, Hisaki Ikebata, Sayuri Kuge, Takeshi Ishihara, Yuichi Iino, Ryo Yoshida.
  • Journal Title: Bioinformatics Volume: 印刷中
  • Peer Reviewed
• [Presentation] 3次元動画像内の非常に多数の細胞領域を自動追跡するための粒子フィルタ手法の開発 (2014)
  • Author(s): 広瀬修, 他
  • Organizer: 人工知能学会全国大会2014 (JSAI2014)
  • Place of Presentation: 愛媛, 日本
• [Presentation] Automated detection and tracking of many cells by using 4D live-cell imaging data (2014)
  • Author(s): Terumasa Tokunaga, et. al.
  • Organizer: 22nd Annual International Conference on Intelligent Systems for Molecular Biology
  • Place of Presentation: Boston, USA.
• [Presentation] 3次元動画像内の非常に多数の細胞領域を自動追跡するための 粒子フィルタ手法の開発 (2014)
  • Author(s): 広瀬修、川口翔太郎、徳永旭将、豊島有、寺本孝行、佐藤賢二、池端久貴、佐藤博文、久下小百合、石原健、飯野雄一、吉田亮
  • Organizer: 人工知能学会全国大会2014 (JSAI2014)
  • Place of Presentation: 愛媛県県民文化会館 (愛媛)
• [Presentation] Automated detection and tracking of many cells by using 4D live-cell imaging data”, 22nd Annual International Conference on Intelligent Systems for Molecular Biology (2014)
  • Author(s): Terumasa Tokunaga, Osamu Hirose, Shotaro Kawaguchi, Yu Toyoshima, Takayuki Teramoto, Hisaki Ikebata, Sayuri Kuge, Takeshi Ishihara, Yuichi Iino, Ryo Yoshida
  • Organizer: 22nd Annual International Conference on Intelligent Systems for Molecular Biology
  • Place of Presentation: Boston, USA
• [Presentation] 逐次的カーネル密度推定法を用いた神経細胞カルシウムイオン分布の定量化 (2013)
  • Author(s): 徳永旭将, 他
  • Organizer: 2013年度統計関連学会連合大会
  • Place of Presentation: 大阪, 日本
• [Presentation] 細胞アノテーションのための3Dデジタルアトラスの作成と神経情報処理の動作原理解明に向けた取り組み (2013)
  • Author(s): 豊島有、久下小百合、寺本孝行、石原健、飯野雄一
  • Organizer: CREST「生命動態の理解と制御のための基盤技術の創出」 第2回領域会議
  • Place of Presentation: 日本科学未来館 (東京)
• [Presentation] 逐次的カーネル密度推定法を用いた神経細胞カルシウムイオン分布の定量化 (2013)
  • Author(s): 徳永旭将、広瀬修、池端久貴、川口翔太郎、豊島有、佐藤博文、寺本孝行、久下小百合、 石原健、飯野雄一、吉田亮
  • Organizer: 2013年度統計関連学会連合大会
  • Place of Presentation: 大阪大学 豊中キャンパス (大阪)
• [Remarks]
  • URL: http://molecular-ethology.biochem.s.u-tokyo.ac.jp/IINO_lab_J.html