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The functional significance of the olivo-cerebellar input in obstacle avoidance during locomotion.

Research Project

Project/Area Number 24800018
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Physical education
Research InstitutionThe University of Tokyo

Principal Investigator

SATO Yamato  東京大学, 総合文化研究科, 助教 (40637914)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords下オリーブ核-登上線維系 / 障害物回避 / 小脳 / ラット / 筋電図 / 下オリーブ核-登上線維系 / 運動制御
Research Abstract

The purpose of this study was to investigate the effect of lesions to the olivo-cerebellar pathway on obstacle avoidance during locomotion. The results are as follows. 1) The post-lesion animals showed excessive toe elevation, shortening stride length and hyper flexion of knee and ankle joints during the swing phase. 2) In post-lesion animals at normal ground locomotion, the vastus lateralis did not show muscle activity during the late swing phase. The biceps femoris showed muscle activity at lift-off. Moreover, the gastrocnemius showed prolongation of quiescent and active period during the stance phase and late swing phase, respectively. 3) In obstacle avoidance during locomotion, the post-lesion animals showed fluctuating toe trajectory. In this case, some muscle (the vastus lateralis, the biceps femoris, the tibialis anterior and the gastrocnemius) of avoiding limb showed different activity from pre-lesion animals.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (7 results)

All 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Lesion in the lateral cerebellum specifically produces overshooting of the toe trajectory in leading forelimb during obstacle avoidance in the rat2013

    • Author(s)
      Sho Aoki, Yamato Sato, and Dai Yanagihara
    • Journal Title

      Journal of Neurophysiology

      Volume: 110(7) Issue: 7 Pages: 1511-1524

    • DOI

      10.1152/jn.01048.2012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of gait ataxia in δ2 glutamate receptor mutant mice, ho15J2012

    • Author(s)
      E. Takeuchi, Y. Sato, E. Miura, H. Yamaura, M. Yuzaki, and D. Yanagihara
    • Journal Title

      PLoS One

      Volume: 7 Issue: 10 Pages: e47553-e47553

    • DOI

      10.1371/journal.pone.0047553

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of leading forelimb movements for obstacle avoidance during locomotion in rats.2012

    • Author(s)
      Aoki S, Sato Y, Yanagihara D.
    • Journal Title

      Neuroscience Research

      Volume: 74 Issue: 2 Pages: 129-137

    • DOI

      10.1016/j.neures.2012.07.007

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 平面歩行における下オリーブ核―登上線維系破壊の影響―2013

    • Author(s)
      佐藤和, 青木祥, 柳原大
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      東京 (口頭発表)
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットの平面歩行運動における小脳皮質中間部の薬理学的不活化の影響2013

    • Author(s)
      青木祥, 佐藤和, 柳原大
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      東京 (口頭発表)
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 平面歩行における下オリーブ核ー登上線維系破壊の影響2013

    • Author(s)
      佐藤和、青木祥、柳原大
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      日本教育会館他(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラットの平面歩行運動における小脳皮質中間部の薬理学的不活化の影響2013

    • Author(s)
      青木祥、佐藤和、柳原大
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      日本教育会館他(東京都千代田区)
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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