Studies on the biofunction of seaweed extract for osteoporosis prevention

Research Project

Project/Area Number	24800026
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Applied health science
Research Institution	Tokyo University of Marine Science and Technology
Principal Investigator	SOGO Nishimoto 東京海洋大学, 海洋科学技術研究科, 准教授 (70392066)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	生理活性 / 海藻 / 骨粗鬆症 / 細胞
Research Abstract	In this study, we found that Gelidium elegans Katzing methanol extract (GME) suppressed the osteoclast differentiation. To clarify this mechanism, we investigated the major and important gene expression in osteoclast differentiation. NFATc1 and JNK gene expression were decreased in osteoclast cultured with GME. It was revealed that GME was operated at the downstream of TRAF6. Moreover, the reduction of gene expression level of JNK and NFATc1 was induced by GME treatment. These results from were suggested that GME carried out suppression of osteoclast differentiation in the intracellular signal transduction via RANK.