Identification of major host genes involved in the malaria parasite proliferation using mice.

Research Project

Project/Area Number	24800031
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Laboratory animal science
Research Institution	Nagoya University
Principal Investigator	UNNO AKIHIRO 名古屋大学, 医学(系)研究科(研究院), 助教 (50628592)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	マラリア / 宿主遺伝子 / 順行性遺伝学 / マウス
Research Abstract	The aim of this study was to examine host genes conferring resistance to infection with the malaria parasite in the Pymr1 locus on mouse Chr.9. (1) Using real-time PCR analysis, we detected that several mRNA levels were higher in malaria-susceptible mice than in malaria-resistant mice. (2) To examine the effects of the gene overexpression on resistance to infection with the parasite, we tried to generate TG mouse lines using mouse BAC clone. Susceptibility analyses using these TG mice are still in preparation.

Report

(3 results)