Kinetics of suppressor T cells in spontaneous tumor-bearing mice
| Project/Area Number |
24800033
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor immunology
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| Research Institution | Mie University |
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Principal Investigator |
SEO Naohiro 三重大学, 医学(系)研究科(研究院), 特任講師 (50283354)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腫瘍所属リンパ節 / γδT細胞 / キラーT細胞 / 制御性T細胞 / 抑制免疫細胞 / 免疫抑制 / 自然発生腫瘍 / 所属リンパ節 / 癌免疫応答 / 抗腫瘍免疫 / T細胞 / Treg細胞 / 自然免疫 |
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| Research Abstract |
IL-10- and IL-17-secreting gamma delta T cells expanded explosively in the medulla and subcapsular sinus of both draining and non-draining lymph nodes of subcutaneous 3-MCA-treated mice around two weeks before tumor formation. Abnormality of the innate IL-10+ IL-17+ gamma delta T cell expansion was demonstrated to be associated with the prevention of systemic circulation and the apoptosis induction of CD107a+ CD8+ mature CTLs and CD4+ Foxp3+ Treg cells in lymph nodes.
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Report
(3 results)
Research Products
(15 results)
