Kinetics of suppressor T cells in spontaneous tumor-bearing mice

• Project/Area Number: 24800033
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Tumor immunology
• Research Institution: Mie University
• Principal Investigator: SEO Naohiro 三重大学, 医学(系)研究科(研究院), 特任講師 (50283354)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 腫瘍所属リンパ節 / γδT細胞 / キラーT細胞 / 制御性T細胞 / 抑制免疫細胞 / 免疫抑制 / 自然発生腫瘍 / 所属リンパ節 / 癌免疫応答 / 抗腫瘍免疫 / T細胞 / Treg細胞 / 自然免疫

Research Abstract

IL-10- and IL-17-secreting gamma delta T cells expanded explosively in the medulla and subcapsular sinus of both draining and non-draining lymph nodes of subcutaneous 3-MCA-treated mice around two weeks before tumor formation. Abnormality of the innate IL-10+ IL-17+ gamma delta T cell expansion was demonstrated to be associated with the prevention of systemic circulation and the apoptosis induction of CD107a+ CD8+ mature CTLs and CD4+ Foxp3+ Treg cells in lymph nodes.

Research Products

• [Journal Article] Systemic CD8^+ T Cell-mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-induced Tumor Necrosis Factor Receptor (2014)
  • Author(s): M Ishihara, N Seo, D Muraoka, J Mitui, M Tanaka, J Mineno, H Ikeda, and H Shiku
  • Journal Title: PLoS One Volume: (掲載決定)
• [Journal Article] 癌と免疫とエキソソーム (2014)
  • Author(s): 瀬尾尚宏, 珠玖洋
  • Journal Title: Drug Delivery System Volume: 29 Pages: 152-159
• [Journal Article] 癌と免疫とエキソソーム. (2014)
  • Author(s): 瀬尾尚宏、珠玖洋
  • Journal Title: Drug Delivery System Volume: 29 Pages: 152-159
• [Journal Article] 経皮ペプチド、タンパク質、DNAワクチンデリバリーの実用化に向けて (2012)
  • Author(s): 瀬尾尚宏, 珠玖洋
  • Journal Title: Drug Delivery System Volume: 27 Pages: 194-201
• [Journal Article] 経皮ペプチド、タンパク質、DNAワクチンデリバリーの実用化にむけて (2012)
  • Author(s): 瀬尾尚宏
  • Journal Title: Drug Delivery System Volume: 27 Pages: 194-201
  • NAID: 130002100515
• [Presentation] Functional Polymer Gel-Exosomes Hybrids for Drug Delivery System and Tissue engineering (2014)
  • Author(s): S Sawad, J Yasuoka, Y Sato, A Shimoda, N Seo, N Harada, H Shiku, and K Akiyoshi
  • Organizer: International Society for Extracellular Vesicles 2014
  • Place of Presentation: Rotterdam, Netherlands
• [Presentation] Functional Polymer Gel-Exosomes Hybrids for Drug Delivery System and Tissue engineering (2014)
  • Author(s): S Sawad, J Yasuoka, Y Sato, A Shimoda, N Seo, N Harada, H Shiku, K Akiyoshi
  • Organizer: International Society for Extracellular Vesicles 2014
  • Place of Presentation: ロッテルダム
• [Presentation] Enhancement of the tumoricidal effects by oncolytic virus HF10 in combination with GITR-specific DTA-1 mAb (2013)
  • Author(s): M Ishihara, N Seo, D Muraoka, M Tanaka, J Mineno, H Ikeda, and H Shiku
  • Organizer: 第72回日本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] マウス皮下移植腫瘍モデルを用いた腫瘍溶解性HSV-1自然変異株HF10療法におけるGITR特異的抗体併用での抗腫瘍効果の検討 (2013)
  • Author(s): M Ishihara, N Seo, D Muraoka, M Tanaka, J Mineno, H Ikeda, and H Shiku
  • Organizer: 第17回日本がん免疫学会
  • Place of Presentation: 宇部
• [Presentation] Enhancement of the tumoricidal effects by oncolytic virus HF-10 in combination with GITR-specific DTA-1 mAb (2013)
  • Author(s): M Ishihara, N Seo, D Muraoka, J Mitui, M Tanaka, J Mineno, H Ikeda, H Shiku
  • Organizer: 第72回日本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] マウス皮下移植腫瘍モデルを用いた 腫瘍溶解性HSV-1自然変異株HF10療法におけるGITR特異的抗体併用での抗腫瘍効果の検討 (2013)
  • Author(s): 石原 幹也、瀬尾 尚宏、村岡 大輔、田中 舞紀、峰野 純一、池田 裕明、珠玖 洋
  • Organizer: 第17回日本がん免疫学会
  • Place of Presentation: 宇部
• [Presentation] PGE2 receptor EP1 and EP4 agonists as an adjuvant for percutaneous peptide immunization (PPI) against murine melanoma (2012)
  • Author(s): N Seo, and H Shiku
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌
• [Presentation] PGE2 receptor EP1 and EP2 agonists as an adjuvant for percutaneous peptide immunization (PPI) against murine melanoma (2012)
  • Author(s): 瀬尾尚宏
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌
• [Book] 内服・注射剤に変わる新規薬剤投与デバイスと簡便な投与経路の開発, 第三節「角質層除去皮膚を利用した経皮抗原デリバリー技術」 (第一部 : 経皮投与デバイスの開発・設計と評価法, 第三章 : マイクロニードル以外の物理的透過促進法の開発) (2014)
  • Author(s): 瀬尾尚宏
  • Publisher: (株)技術情報協会 (東京) (掲載決定)
• [Book] 第三節、角質層除去皮膚を利用した経皮抗原デリバリー技術（第一部、経皮投与デバイスの開発・設計と評価法、第三章、マイクロニードル以外の物理的透過促進法の開発）『内服・注射剤に変わる新規薬剤投与デバイスと簡便な投与経路の開発』 (2014)
  • Author(s): 瀬尾尚宏
  • Total Pages: 8
  • Publisher: （株）技術情報協会