Assessment of myocardial ischemia using 3D contrast speckle tracking echocardiography

• Project/Area Number: 24800039
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Osaka University
• Principal Investigator: MASUDA Kasumi 大阪大学, 医学(系)研究科(研究院), 助教 (20533293)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 超音波医学 / 虚血診断

Research Abstract

Three-dimensional (3D) speckle tracking imaging allows us to assess circumferential, longitudinal and radial strains in the same beat. However, low frame rates and low image quality of 3D speckle tracking echocardiography are potential limitation to quantify the left ventricular (LV) function. Echocardiographic contrast agents improve endocardial definition, allowing the accurate quantification of LV volumes and the assessment of wall motion abnormalities. From animal experiment, we found that 3D speckle tracking echocardiography with contrast (30 ml/min intravenous infusion, mechanical index -14 dB) was the more reproducible technique for the strain analysis than 2D speckle tracking echocardiography.

Research Products

• [Journal Article] Myocardial layer-specific analysis of ischemic memory using speckle tracking echocardiography (2014)
  • Author(s): Daisuke Sakurai, Toshihiko Asanuma, Kasumi Masuda, Ayana Hioki, and Satoshi Nakatani
  • Journal Title: Int J Cardiovasc Imaging Volume: 30 Pages: 739-748
  • NAID: 120007191909
  • Peer Reviewed
• [Journal Article] Myocardial layer-specific analysis of ischemic memory imaging using speckle tracking echocardiography (2014)
  • Author(s): Sakurai D, Asanuma T, Masuda K, Hioki A, Nakatani S.
  • Journal Title: Int J Cardiovasc Imaging Volume: 30 Issue: 4 Pages: 739-748
  • DOI: 10.1007/s10554-014-0388-x
  • Peer Reviewed
• [Journal Article] Comparison of the effects of angiotensin II receptor antagonist monotherapy and combination therapy with a diuretic on cardiac function in spontaneously hypertensive rats (2012)
  • Author(s): Kasumi Masuda, Hiroki Taenaka, Toshihiko Asanuma, and Satoshi Nakatani
  • Journal Title: J Echocardiogr Volume: 10 Pages: 125-131
  • NAID: 10031136196
  • Peer Reviewed
• [Presentation] Assessment of early systolic lengthening may be useful to detect ischemic memory (2014)
  • Author(s): Masuda K, Asanuma T, Koriyama H, Sakurai D, Oka M, Kotani K, and Nakatani S
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-03-23
• [Presentation] Assessment of early systolic lengthening may be useful to detect ischemic memory (2014)
  • Author(s): Kasumi Masuda, Toshihiko Asanuma, Hikaru Koriyama, Daisuke Sakurai, Satoshi Nakatani
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] 心筋虚血メモリーのメカニズム : なぜpost-systolic shorteningは残存するのか (2013)
  • Author(s): 増田佳純, 浅沼俊彦, 郡山晃, 櫻井大輔, 中谷敏
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2013-05-24
• [Presentation] Post-systolic shorteningによる虚血メモリー評価はラットにおいても可能か (2013)
  • Author(s): 種谷遼太, 浅沼俊彦, 増田佳純, 中谷敏
  • Organizer: 第24回日本心エコー図学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-27
• [Presentation] 3Dスペックルトラッキング法を用いた新しい左室充満圧の推定法 : E/e'との比較 (2013)
  • Author(s): 櫻井大輔, 浅沼俊彦, 増田佳純, 郡山晃, 中谷敏
  • Organizer: 第24回日本心エコー図学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-26
• [Presentation] Myocardial ischemic memory assessed by 3D speckle tracking echocardiography : Comparison of circumferential, longitudinal and radial strains (2013)
  • Author(s): Masuda K, Asanuma T, Koriyama H, Sakurai D, and Nakatani S
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-17
• [Presentation] Mechanism of myocardial ischemic memory : why does post-systolic shortening persist after brief ischemia? (2013)
  • Author(s): Masuda K, Asanuma T, Koriyama H, Sakurai D, and Nakatani S
  • Organizer: ESC Congress 2013
  • Place of Presentation: Amsterdam RAI, オランダ
• [Presentation] Quantification of the energy loss in the left ventricle using color Doppler-based Vector Flow Mapping in a dog model of aortic regurgitation (2013)
  • Author(s): Koriyama H, Masuda K, Sakurai D, Asanuma T, Itatani K, Miyaji K, and Nakatani S
  • Organizer: American Heart Association's scientific sessions 2013
  • Place of Presentation: Dallas, USA.
• [Presentation] Beneficial effect of combination of Losartan and hydrochlorothiazide on diastolic heart failure is independent of antihypertensive effect : A study using Dahl salt-sensitive rats (2013)
  • Author(s): Adachi T, Masuda K, Asanuma T, and Nakatani S
  • Organizer: American Heart Association's scientific sessions 2013
  • Place of Presentation: Dallas, USA.
• [Presentation] 3Dスペックルトラッキング法を用いた新しい左室充満圧の推定法：E/e’との比較 (2013)
  • Author(s): 櫻井大輔、浅沼 俊彦、増田 佳純、郡山 晃、中谷 敏
  • Organizer: 第 24回日本心エコー図学会学術集会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] Post-systolic shorteningによる虚血メモリー評価はラットにおいても可能か (2013)
  • Author(s): 種谷 遼太、浅沼 俊彦、増田 佳純、中谷 敏
  • Organizer: 第 24回日本心エコー図学会学術集会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] 心筋虚血メモリーのメカニズム：なぜpost-systolic shorteningは残存するのか (2013)
  • Author(s): 増田 佳純、浅沼 俊彦、櫻井 大輔、郡山 晃、中谷 敏
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] Mechanism of myocardial ischemic memory: why does post-systolic shortening persist after brief ischemia? (2013)
  • Author(s): Kasumi Masuda, Toshihiko Asanuma, Hikaru Koriyama, Daisuke Sakurai, Satoshi Nakatani
  • Organizer: ESC Congress 2013
  • Place of Presentation: Amsterdam RAI、オランダ
• [Presentation] Quantification of the Energy Loss in the Left Ventricle Using Color Doppler-Based Vector Flow Mapping in a Dog Model of Aortic Regurgitation (2013)
  • Author(s): Hikaru Koriyama, Kasumi Masuda, Daisuke Sakurai, Toshihiko Asanuma, Keiichi Itatani, Kagami Miyaji, Satoshi Nakatani
  • Organizer: American Heart Association’s scientific sessions 2013
  • Place of Presentation: Dallas Convention Center、USA
• [Presentation] Beneficial Effect of Combination of Losartan and Hydrochlorothiazide on Diastolic Heart Failure is Independent of Antihypertensive Effect: A Study Using Dahl Salt-Sensitive Rats (2013)
  • Author(s): Tetsuya Adachi, Kasumi Masuda, Toshihiko Asanuma, Satoshi Nakatani
  • Organizer: American Heart Association’s scientific sessions 2013
  • Place of Presentation: Dallas Convention Center、USA
• [Presentation] 3Dスペックルトラッキング法を用いた心筋虚血メモリー評価 (2012)
  • Author(s): 増田佳純, 浅沼俊彦, 郡山晃, 櫻井大輔, 中谷敏
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2012-09-15
• [Presentation] 3Dスペックルトラッキング法による新しい左房圧推定法 (2012)
  • Author(s): 櫻井大輔, 浅沼俊彦, 増田佳純, 郡山晃, 中谷敏
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2012-09-15
• [Presentation] Effect of sonoporation with bubble liposomes on vegetations using rat model of experimental endocarditis (2012)
  • Author(s): Masuda K, Yamashita M, Asanuma T, Suzuki R, Maruyama K, Mitsutake K, and Nakatani S
  • Organizer: 第23回日本心エコー図学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2012-04-19
• [Presentation] Feasibility of sonoporation using nano-sized bubble liposomes as treatment of infective endocarditis : A Study on rat model of experimental endocarditis (2012)
  • Author(s): Masuda K, Yamashita M, Asanuma T, Suzuki R, Maruyama K, Mitsutake K, and Nakatani S
  • Organizer: 23nd Annual Scientific Sessions of the American Society of Echocardiography
  • Place of Presentation: National Harbor, USA.
• [Presentation] Sonoporation with nano-sized bubble liposomes may be a useful method of drug delivery to vegetations : An experimental study using rats with infective endocarditis (2012)
  • Author(s): Masuda K, Yamashita M, Asanuma T, Suzuki R, Maruyama K, Mitsutake K, and Nakatani S
  • Organizer: American Heart Association's scientific sessions 2012
  • Place of Presentation: Los Angeles, USA.
• [Presentation] Assessment of myocardial ischemic memory using 3-dimensional speckle tracking echocardiography (2012)
  • Author(s): Masuda K, Asanuma T, Koriyama H, Sakurai D, and Nakatani S
  • Organizer: American Heart Association's scientific sessions 2012
  • Place of Presentation: Los Angeles, USA.
• [Presentation] New index derived from 3-dimensional speckle tracking echocardiography for the estimation of left atrial pressure (2012)
  • Author(s): Sakurai D, Asanuma T, Masuda K, Koriyama H, and Nakatani S
  • Organizer: American Heart Association's scientific sessions 2012
  • Place of Presentation: Los Angeles, USA.
• [Presentation] Sonoporation with nano-sized bubble liposomes is a useful method of drug delivery to vegetations using rats with endocarditis
  • Author(s): Kasumi Masuda
  • Organizer: American Heart Association’s scientific sessions 2012
  • Place of Presentation: Los Angeles, USA
• [Presentation] Assessment of myocardial ischemic memory using 3D speckle tracking echocardiography
  • Author(s): Kasumi Masuda
  • Organizer: American Heart Association’s scientific sessions 2012
  • Place of Presentation: Los Angeles, USA
• [Presentation] Myocardial ischemic memory assessed by 3D speckle tracking echocardiography: Comparison of circumferential, longitudinal and radial strains
  • Author(s): Kasumi Masuda
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜