Identifying Brain Imaging Biomarker using Regularity Dimension for Studying Age Related Cognitive Decline
| Project/Area Number |
24800052
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Intelligent informatics
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| Research Institution | The University of Aizu |
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Principal Investigator |
PHAM Tuan Duc 会津大学, 先端情報科学研究センター, 教授 (70631472)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳画像バイオマーカー / Neuroinformatics / Dementia / Brain MRI / Nonlinear dynamics / Chaos / Pattern recognition / MRI / Regularity dimension / Sample entropy / アルツハイマー型認知症 / 老化 |
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| Research Abstract |
We found an increasing cortical structural irregularity with aging which might indicate an age-related exacerbation of cortical structural irregularity. This supports previous MRI-volumetric observations that cortical atrophy occurred before the onset of dementia, progressed with aging, and accelerated once dementia starts. We depicted a profile of the increasing complexity in cortical surface structure from young health to clinically healthy elders, then to clinically diagnosed AD. Particularly, we detected a significant difference between elder dements and their age- and gender-matched controls. This demonstrated acceleration of brain aging in those elder demented individuals which align with the concept of progressive neuro-degeneration in AD individuals. Alzheimer's disease may exhibit a characteristic pattern of atrophy different from that due to aging, even accelerated aging.
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Report
(3 results)
Research Products
(9 results)
