Effect of moderate-intensity exercise and heat stimulation on inactivity-induced insulin resistance

• Project/Area Number: 24800079
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Nagaoka National College of Technology
• Principal Investigator: KAWAMOTO EMI 長岡工業高等専門学校, その他部局等, 助教 (40634514)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 不活動 / インスリン抵抗性 / 骨格筋 / 軽運動 / 温熱処置

Research Abstract

Chronic muscle disuse - produced by the condition of physical inactivity induced insulin resistance in human skeletal muscle. I studied whether moderate-intensity exercise and heat stimulation that led to a significant amplification in phosphorylation of AMP-activated protein kinase (AMPK), prevented insulin resistance that induced in postural muscle by hindlimb immobilization. As a result, our study suggested that it was necessary to activate AMPK to a sufficiently level for preventing inactivity-induced insulin resistance.

Research Products

• [Journal Article] Elevation of muscle temperature stimulates muscle glucose uptake in vivo and in vitro (2013)
  • Author(s): Koshinaka K, Kawamoto E, Abe N, Toshinai K, Nakazato M, Kawanaka K
  • Journal Title: J. Physiol Sci Volume: 63 Pages: 409-418
  • NAID: 40019850683
  • Peer Reviewed
• [Journal Article] Elevation of muscle temperature stimulates muscle glucose uptake in vivo and in vitro. (2013)
  • Author(s): Koshinaka K, Kawamoto E, Abe N, Toshinai K, Nakazato M, Kawanaka K.
  • Journal Title: J Physiol Sci Volume: 63 Issue: 6 Pages: 409-418
  • DOI: 10.1007/s12576-013-0278-3
  • Peer Reviewed
• [Presentation] 身体不活動が骨格筋にインスリン抵抗性を引き起こす分子機序に関する研究 (2013)
  • Author(s): 河本絵美
  • Organizer: 平成25年女性研究者交流会
  • Place of Presentation: 東京
  • Year and Date: 2013-12-20
• [Presentation] ラットヒラメ筋における運動後のインスリン感受性上昇の機序 (2013)
  • Author(s): 川中健太郎，岩部万衣子，星野芙美，河本絵美，越中敬一
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 熱刺激による骨格筋の糖取り込み亢進作用はAMPKとPI3Kを介する (2012)
  • Author(s): 越中敬一,河本絵美,阿部夏希,十枝内厚次,中里雅光,川中健太郎
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 岐阜
• [Remarks] 長岡高専物質工学科ホームページ
  • URL: http://www.nagaoka-ct.ac.jp/mb/