investigation of geometical distortion for image analysis and development of classification in alzheimer's disease

• Project/Area Number: 24800089
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: 独立行政法人国立精神・神経医療研究センター
• Principal Investigator: MAIKUSA Norihide 独立行政法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 研究員 (80631069)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MRI / 歪み補正 / アルツハイマー病

Research Abstract

Alzheimer's disease (Alzheimer disease: AD) is the most serious dementia to affect cognitive functions. AD therapeutic drugs have been developing in the world, but it is pointed out for the enforcement to entail a vast cost with long time when it becomes the clinical trial. Image analysis using the MRI is effective for a clinical investigation evaluation of Alzheimer's disease, however the geometric distortion in the image ill-affect the reliability of image analysis. In this study, I developed correction method of geometrical distortion to improve this problem and this findings promote clinical investigation enforcement.

Research Products

• [Journal Article] Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom (2013)
  • Author(s): Norihide Maikusa, Fumio Yamashita, Kenichiro Tanaka, Osamu Abe, Atsushi Kawaguchi, Hiroyuki Kabasawa, Shoma Chiba, Akihiro Kasahara, Nobuhisa Kobayashi, Tetsuya Yuasa, Noriko Sato, Hiroshi Matsuda, Takeshi Iwatsubo
  • Journal Title: Medical Physics Volume: 40 Issue: 6Part1 Pages: 62303-62303
  • DOI: 10.1118/1.4801913
  • Peer Reviewed
• [Journal Article] Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom. (2013)
  • Author(s): .Maikusa N, Yamashita F, Tanaka K, Abe O, Kawaguchi A, Kabasawa H, Chiba S, Kasahara A, Kobayashi N, Yuasa T, Sato N, Matsuda H, Iwatsubo T
  • Journal Title: Medical physics Volume: 40 Pages: 62303-62303
  • Peer Reviewed
• [Journal Article] IMPROVED VOLUMETRIC MEASUREMENT OF BRAIN STRUCTURE WITH A DISTORTION CORRECTION PROCEDURE USING AN ADNI PHANTOM (2013)
  • Author(s): Norihide Maikusa et. al
  • Journal Title: Medcal Physics Volume: 40
  • Peer Reviewed
• [Presentation] PET/CTにおける脳アミロイド沈着定量の標準化～SPMによるSUVR画像の自動生成～ (2014)
  • Author(s): 佐々木啓,舞草伯秀,今林悦子,湯浅哲也,松田博史
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: Boston Convention and Exhibition Center(沖縄テンブス館,沖縄) (MI2013-115, No.410)
• [Presentation] "PET/CTにおける脳アミロイド沈着定量の標準化 ～ SPMによるSUVR画像の自動生成 ～" (2014)
  • Author(s): 佐々木啓, 舞草伯秀, 今林悦子, 湯浅哲也, 松田博史
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 沖縄デンブス館, 沖縄
• [Presentation] Effect of a phantom-based distortion correction of MRI for assessment of Alzheimer's disease using a tensor-based morphometry (2013)
  • Author(s): Maikusa N, Fujishima M, Chida M, Matsuda H, Sato N, Iwatsubo T
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Boston Convention and Exhibition Center, Boston
• [Presentation] Effect of Apolipoprotein E-ε4status on brain atrophy in 1-year repeat MRI data form cognitively normal individuals (2013)
  • Author(s): Matsuda H, Fushishima M, Maikusa N, Chida N, Kuwano R, Iwatsubo T
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Boston Convention and Exhibition Center, Boston
• [Presentation] Machine-learning classification of MR scans in Alzheimer's disease based on tensor-based morphometry (2013)
  • Author(s): Fujishima M, Yamashita F, Matsuda H, Maikusa N, Chida N, Iwatsubo T
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Boston Convention and Exhibition Center, Boston
• [Presentation] 海馬自動セグメンテーション3法の精度比較と機械学習を用いたエラー検出・訂正による精度向上 (2013)
  • Author(s): 藤島基宣,舞草伯秀,松田博史,岩坪威
  • Organizer: 第41回日本磁気共鳴学会大会
  • Place of Presentation: アスティとくしま,徳島)
• [Presentation] 健常者でのアポリポ蛋白Eε4保因者と非保因者のMRIによる縦断的評価:J‐ADNI研究 (2013)
  • Author(s): 松田博史,舞草伯秀,藤島基宣,千田哲子,桑野良三,石井賢二,岩坪威
  • Organizer: 第72回日本医学放射線学会総会抄録集
  • Place of Presentation: アスティとくしま,徳島 (S307)
• [Presentation] Effect of a phantom-based distortion correction of MRI for assessment of Alzheimer’s disease using a tensor-based morphometry (2013)
  • Author(s): Maikusa N, Fujishima M, Chida M, Matsuda H, Sato N, Iwatsubo T
  • Organizer: Alzheimer’s Association International Conference
  • Place of Presentation: Boston Convention and Exhibition Center,Boston
• [Presentation] Effect of Apolipoprotein E-ε４ status on brain atrophy in 1-year repeat MRI data form cognitively normal individuals (2013)
  • Author(s): Matsuda H, Fushishima M, Maikusa N, Chida N, Kuwano R, Iwatsubo T
  • Organizer: Alzheimer’s Association International Conference
  • Place of Presentation: Boston Convention and Exhibition Center,Boston
• [Presentation] Machine-learning classification of MR scans in Alzheimer’s disease based on tensor-based morphometry (2013)
  • Author(s): Fujishima M, Yamashita F, Matsuda H, Maikusa N, Chida N, Iwatsubo T
  • Organizer: Alzheimer’s Association International Conference
  • Place of Presentation: Boston Convention and Exhibition Center,Boston
• [Presentation] 海馬自動セグメンテーション3法の精度比較と機械学習を用いたエラー検出・訂正による精度向上 (2013)
  • Author(s): 藤島基宣, 舞草伯秀, 松田博史, 岩坪威
  • Organizer: 日本磁気共鳴学会大会
  • Place of Presentation: アスティとくしま, 徳島
• [Presentation] 健常者でのアポリポ蛋白Eε4保因者と非保因者のMRIによる縦断的評価:J‐ADNI研究 (2013)
  • Author(s): 松田博史, 舞草伯秀, 藤島基宣, 千田哲子, 桑野良三, 石井賢二, 岩坪威
  • Organizer: 日本磁気共鳴学会大会
  • Place of Presentation: アスティとくしま, 徳島
• [Book] すぐできるVBM精神・神経疾患の脳画像解析SPM12対応DVD付 (2014)
  • Author(s): 根本清貴(著,編集),青木茂樹(監修),笠井清登(監修)
  • Publisher: 学研メディカル秀潤社
• [Book] “すぐできるＶＢＭ 精神・神経疾患の脳画像解析 ＳＰＭ１２対応 ＤＶＤ付” (2014)
  • Author(s): 根本清貴 (著, 編集), 青木茂樹 (監修), 笠井清登 (監修)
  • Total Pages: 146
  • Publisher: 学研メディカル秀潤社