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investigation of geometical distortion for image analysis and development of classification in alzheimer's disease

Research Project

Project/Area Number 24800089
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Medical systems
Research Institution独立行政法人国立精神・神経医療研究センター

Principal Investigator

MAIKUSA Norihide  独立行政法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 研究員 (80631069)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMRI / 歪み補正 / アルツハイマー病
Research Abstract

Alzheimer's disease (Alzheimer disease: AD) is the most serious dementia to affect cognitive functions. AD therapeutic drugs have been developing in the world, but it is pointed out for the enforcement to entail a vast cost with long time when it becomes the clinical trial. Image analysis using the MRI is effective for a clinical investigation evaluation of Alzheimer's disease, however the geometric distortion in the image ill-affect the reliability of image analysis. In this study, I developed correction method of geometrical distortion to improve this problem and this findings promote clinical investigation enforcement.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (17 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom2013

    • Author(s)
      Norihide Maikusa, Fumio Yamashita, Kenichiro Tanaka, Osamu Abe, Atsushi Kawaguchi, Hiroyuki Kabasawa, Shoma Chiba, Akihiro Kasahara, Nobuhisa Kobayashi, Tetsuya Yuasa, Noriko Sato, Hiroshi Matsuda, Takeshi Iwatsubo
    • Journal Title

      Medical Physics

      Volume: 40 Issue: 6Part1 Pages: 62303-62303

    • DOI

      10.1118/1.4801913

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom.2013

    • Author(s)
      .Maikusa N, Yamashita F, Tanaka K, Abe O, Kawaguchi A, Kabasawa H, Chiba S, Kasahara A, Kobayashi N, Yuasa T, Sato N, Matsuda H, Iwatsubo T
    • Journal Title

      Medical physics

      Volume: 40 Pages: 62303-62303

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IMPROVED VOLUMETRIC MEASUREMENT OF BRAIN STRUCTURE WITH A DISTORTION CORRECTION PROCEDURE USING AN ADNI PHANTOM2013

    • Author(s)
      Norihide Maikusa et. al
    • Journal Title

      Medcal Physics

      Volume: 40

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] PET/CTにおける脳アミロイド沈着定量の標準化~SPMによるSUVR画像の自動生成~2014

    • Author(s)
      佐々木啓,舞草伯秀,今林悦子,湯浅哲也,松田博史
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      Boston Convention and Exhibition Center(沖縄テンブス館,沖縄) (MI2013-115, No.410)
    • Related Report
      2013 Final Research Report
  • [Presentation] "PET/CTにおける脳アミロイド沈着定量の標準化 ~ SPMによるSUVR画像の自動生成 ~"2014

    • Author(s)
      佐々木啓, 舞草伯秀, 今林悦子, 湯浅哲也, 松田博史
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      沖縄デンブス館, 沖縄
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of a phantom-based distortion correction of MRI for assessment of Alzheimer's disease using a tensor-based morphometry2013

    • Author(s)
      Maikusa N, Fujishima M, Chida M, Matsuda H, Sato N, Iwatsubo T
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Boston Convention and Exhibition Center, Boston
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of Apolipoprotein E-ε4status on brain atrophy in 1-year repeat MRI data form cognitively normal individuals2013

    • Author(s)
      Matsuda H, Fushishima M, Maikusa N, Chida N, Kuwano R, Iwatsubo T
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Boston Convention and Exhibition Center, Boston
    • Related Report
      2013 Final Research Report
  • [Presentation] Machine-learning classification of MR scans in Alzheimer's disease based on tensor-based morphometry2013

    • Author(s)
      Fujishima M, Yamashita F, Matsuda H, Maikusa N, Chida N, Iwatsubo T
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Boston Convention and Exhibition Center, Boston
    • Related Report
      2013 Final Research Report
  • [Presentation] 海馬自動セグメンテーション3法の精度比較と機械学習を用いたエラー検出・訂正による精度向上2013

    • Author(s)
      藤島基宣,舞草伯秀,松田博史,岩坪威
    • Organizer
      第41回日本磁気共鳴学会大会
    • Place of Presentation
      アスティとくしま,徳島)
    • Related Report
      2013 Final Research Report
  • [Presentation] 健常者でのアポリポ蛋白Eε4保因者と非保因者のMRIによる縦断的評価:J‐ADNI研究2013

    • Author(s)
      松田博史,舞草伯秀,藤島基宣,千田哲子,桑野良三,石井賢二,岩坪威
    • Organizer
      第72回日本医学放射線学会総会抄録集
    • Place of Presentation
      アスティとくしま,徳島 (S307)
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of a phantom-based distortion correction of MRI for assessment of Alzheimer’s disease using a tensor-based morphometry2013

    • Author(s)
      Maikusa N, Fujishima M, Chida M, Matsuda H, Sato N, Iwatsubo T
    • Organizer
      Alzheimer’s Association International Conference
    • Place of Presentation
      Boston Convention and Exhibition Center,Boston
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of Apolipoprotein E-ε4 status on brain atrophy in 1-year repeat MRI data form cognitively normal individuals2013

    • Author(s)
      Matsuda H, Fushishima M, Maikusa N, Chida N, Kuwano R, Iwatsubo T
    • Organizer
      Alzheimer’s Association International Conference
    • Place of Presentation
      Boston Convention and Exhibition Center,Boston
    • Related Report
      2013 Annual Research Report
  • [Presentation] Machine-learning classification of MR scans in Alzheimer’s disease based on tensor-based morphometry2013

    • Author(s)
      Fujishima M, Yamashita F, Matsuda H, Maikusa N, Chida N, Iwatsubo T
    • Organizer
      Alzheimer’s Association International Conference
    • Place of Presentation
      Boston Convention and Exhibition Center,Boston
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海馬自動セグメンテーション3法の精度比較と機械学習を用いたエラー検出・訂正による精度向上2013

    • Author(s)
      藤島基宣, 舞草伯秀, 松田博史, 岩坪威
    • Organizer
      日本磁気共鳴学会大会
    • Place of Presentation
      アスティとくしま, 徳島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 健常者でのアポリポ蛋白Eε4保因者と非保因者のMRIによる縦断的評価:J‐ADNI研究2013

    • Author(s)
      松田博史, 舞草伯秀, 藤島基宣, 千田哲子, 桑野良三, 石井賢二, 岩坪威
    • Organizer
      日本磁気共鳴学会大会
    • Place of Presentation
      アスティとくしま, 徳島
    • Related Report
      2013 Annual Research Report
  • [Book] すぐできるVBM精神・神経疾患の脳画像解析SPM12対応DVD付2014

    • Author(s)
      根本清貴(著,編集),青木茂樹(監修),笠井清登(監修)
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2013 Final Research Report
  • [Book] “すぐできるVBM 精神・神経疾患の脳画像解析 SPM12対応 DVD付”2014

    • Author(s)
      根本清貴 (著, 編集), 青木茂樹 (監修), 笠井清登 (監修)
    • Total Pages
      146
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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