Analysis of the role of immune system in intestinal carcinogenesis and metastasis using a mouse model

• Project/Area Number: 24800093
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: 愛知県がんセンター(研究所)
• Principal Investigator: KAJINO Rie 愛知県がんセンター(研究所), 分子病態学部, 研究員 (20633184)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 癌 / 免疫学 / シグナル伝達

Research Abstract

(1) JNK-mTORC1 pathway is activated in intestinal tumors developed in ApcD716 mutant mice. Experiments using intestinal organoid culture established from wild-type and ApcD716 mutant mice suggest that the JNK-mTORC1 pathway is activated by extracellular signals, rather than via cell autonomous mechanisms.
(2) cis-ApcD716/Smad4 compound mutant mice develop tumors that show local invasion. Changes in the composition of intestinal microbiota by antibiotics administration affected colorectal tumorigenesis in cis-ApcD716/Smad4 mutant mice.