Structure Activity Relationships Study of Ingenols for Novel Anti-HIV Drugs
| Project/Area Number |
24810001
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OHYOSHI TAKAYUKI 筑波大学, 国際統合睡眠医科学研究機構, 助教 (90639303)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 13－オキシインゲノール / インゲノール / 構造活性相関研究 / HIV活性 / PKC活性 / 天然物化学 / 13‐オキシインゲノール / inside-outside炭素骨格 / 13-オキシインゲノール |
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| Research Abstract |
13-Oxyingenol is a diterpenoid isolated from the plants of Euphorbia sp. 13-Oxyingenol and it's derivatives have strong anti HIV activity and PKC activation. I synthesized many 13-oxyingenol derivatives and measured PKC activation. Also, I have achieved the synthesis of the tetracyclic skeleton of ingenol based on total synthesis of 13-oxyingenol.
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Report
(3 results)
Research Products
(4 results)
