Functional analysis of a transcriptional feedback loop related to a mammalian clock gene, Period
| Project/Area Number |
24810009
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Genome biology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 時計遺伝子 / Period / サーカディアンリズム / 概日リズム / 転写制御因子 / ネガティブフィードバック機構 |
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| Research Abstract |
We investigated a novel function of transcriptional feedback loop relevant to a mammalian clock gene, Period. Here, we report that a new transcription factor was identified as physically binding with Per2, and the transcription factor inhibited E-box regulated transcriptional activity by Bmal1/Clock. Further, we found that the transcription factor accelerated nuclear translocation of Per2, in addition inhibited Per2 degradation induced by casein kinase I. Accordingly, the transcription factor could play a role as a novel function of transcriptional regulation through the direct interaction with Per2.
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Report
(3 results)
Research Products
(2 results)
