| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We reported the design, synthesis, and application of sulfonyl 3-alkynyl pantetheinamides that can cross-link acyl carrier proteins (ACPs) with beta-hydroxy-ACP dehydratase (DH) domains. This cross-linking strategy provides potential to investigate these enzymes in their native binding states by offering easy access to mechanistically cross-linked enzyme species.
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